Prevalence and Characteristics of Pulmonary Embolism on COVID-19 Patients Presenting Respiratory Symptoms

NCT04420312 | Completed

• 2 other identifiers: COVID-EPMR 4516150520
• Study Type: observational
• Target: 1,024
• Locations: 1 country
• Sites: 1

Brief Summary

Multicentric case-control study that is aims at:

• evaluating the prevalence of pulmonary embolism among a large population of consecutive patients admitted for COVID-19 pneumonia into two large university hospitals in Paris, France: Groupe Hospitalier Paris Saint-Joseph (GHPSJ) and Hôpital Européen Georges Pompidou (HEGP)
• and identifying the characteristics associated with pulmonary embolism by using a nested case control study design within the patients who underwent either unenhanced computed tomograpghy (CT) or CT pulmonary angiogram (CTPA) evaluation.

Conditions

Pulmonary Embolism; Covid-19

Keywords

pulmonary embolism; covid-19; CT; D-Dimers; ARDS

Outcome Measures

Primary Outcomes (1)

• Impact of PE on COVID-19 patients

  Evaluate the prevalence of Pulmonary embolism among a large population of consecutive COVID-19 patients presenting respiratory symptoms

  March 1st, 2020

Secondary Outcomes (1)

• Clinical and radiological characteristics

  April 20th,2020

Study Arms (2)

Group 1

Enrolled the Covid-19 patients with a negative CT Pulmonary Angiogram.

Group 2

Enrolled the Covid-19 patients in whom only a CT was performed.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients aged over 18 years, hospitalized for respiratory pathology, associated with the COVID-19; confirmed by either a RT-PCR test or a CT scan.

You may qualify if:

• patients \>18 years,
• admitted for acute COVID-19 pneumonia and have recieved a chest CT scan during hospitalization,
• COVID-19 diagnosis confirmed by a positive result of a RT-PCR,
• CT findings of COVID-19 pneumonia.

You may not qualify if:

• Respiratory distress syndrome explained by other cause
• Patients who refuse to participate to the study.

Sponsors & Collaborators

• Fondation Hôpital Saint-Joseph: lead

Study Sites (1)

Groupe Hospitalier Paris Saint-Joseph

Paris, 75014, France

Location

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MeSH Terms

Conditions

Pulmonary Embolism; COVID-19

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Embolism; Embolism and Thrombosis; Vascular Diseases; Cardiovascular Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: June 5, 2020
• First Posted: June 9, 2020
• Study Start: March 1, 2020
• Primary Completion: April 20, 2020
• Study Completion: April 20, 2020
• Last Updated: June 25, 2020

Record last verified: 2020-06

Locations

FR (1)