Looking for Minimum Dose to Induce Sympathectomy in Infraclavicular Brachial Plexus Block
1 other identifier
observational
66
0 countries
N/A
Brief Summary
For patients who undergoing hemodialysis, it is important to have good AV fistula. One third of AV fistula usually fail during early stage. It is helpful to use nerve block to dilate the blood vessels and enhance the prognosis. But 0.2% Ropivacaine usually cause muscle weakness in present studies. The investigators hope to find the lowest concentration to provide sympathectomy without muscle weakness. Because the patients with hemodialysis usually have multiple co-morbidity, thus we choose patients with forearm fracture at the first place. With this result, the investigators can design further study for patients with hemodialysis. The investigators prefer proximal approach because brachial plexus run together in the cosctoclavicular space and show lower incidence of incomplete work.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P25-P50 for all trials
Started Jun 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 31, 2020
CompletedFirst Posted
Study publicly available on registry
June 4, 2020
CompletedStudy Start
First participant enrolled
June 4, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 4, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
July 4, 2021
CompletedJune 4, 2020
June 1, 2020
1.1 years
May 31, 2020
June 3, 2020
Conditions
Outcome Measures
Primary Outcomes (3)
Change of diameter of basilic vein and brachial artery
Use ultrasound to measure the difference of diameter at different time point.
Change from baseline diameter(pre-nerve block) at 45min
Change of diameter of basilic vein and brachial artery
Use ultrasound to measure the difference of diameter at different time point.
Change from baseline diameter(pre-nerve block) at 24hour
Change of diameter of basilic vein and brachial artery
Use ultrasound to measure the difference of diameter at different time point.
Change from baseline diameter(pre-nerve block) at 48hour
Secondary Outcomes (5)
Sensory block of upper limb
45min post nerve block
Sensory block of upper limb
24hour post nerve block
Motor block of upper limb
45min post nerve block
Motor block of upper limb
24hour post nerve block
Motor block of upper limb
48hour post nerve block
Interventions
Ultrasound-guided infraclavicular brachial plexus block
Eligibility Criteria
Patients who are scheduled for upper limb surgery
You may qualify if:
- Age between 20-80 y/o, BW: 40-90 kilograms，ASA class I-III，No pre-existing neuropathy，Scheduled for upper limb surgery.
You may not qualify if:
- Pre-existing neuropathy (ex: polyneuropathy)
- History of allergy to xylocaine、ropivacaine、epinephrine
- Emergent surgery
- Coagulopathy
- Patient who can not express themselves
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
May 31, 2020
First Posted
June 4, 2020
Study Start
June 4, 2020
Primary Completion
July 4, 2021
Study Completion
July 4, 2021
Last Updated
June 4, 2020
Record last verified: 2020-06