Association Between Telomere Length and Cardiac Dysfunction
Association Between Relative Telomere Length and Severity of Cardiac Dysfunction
1 other identifier
observational
300
1 country
1
Brief Summary
Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jan 2019
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
January 1, 2019
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2020
CompletedFirst Submitted
Initial submission to the registry
May 27, 2020
CompletedFirst Posted
Study publicly available on registry
June 1, 2020
CompletedJune 1, 2020
May 1, 2020
1.3 years
May 27, 2020
May 27, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
Relative telomere length
The ratio of RTL to hemoglobin contents was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA contents.Relative expression of mtDNA were measured in young adults suffered from AL.
From date of admission until the date of discharging from hospital, assessed up to 5 days
Study Arms (1)
acute leukemia group
300 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy
Interventions
Relative telomere length in peripheral blood cell
Eligibility Criteria
A total of 300 eligible acute leukemia patients were anticipated to include in this study.
You may qualify if:
- \. histological confirmed acute leukemia; 2. Preparing for chemotherapy;
You may not qualify if:
- history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Xiao-Fan Zhu
Tianjin, Tianjin Municipality, 300000, China
Biospecimen
Relative telomere length in peripheral blood cell
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- CASE CONTROL
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr.
Study Record Dates
First Submitted
May 27, 2020
First Posted
June 1, 2020
Study Start
January 1, 2019
Primary Completion
May 1, 2020
Study Completion
May 1, 2020
Last Updated
June 1, 2020
Record last verified: 2020-05
Data Sharing
- IPD Sharing
- Will not share