Change in the Ratio of Mean Platelet Volume (MPV) to Platellet(PLT) in Covid-19 Pneumonia Patients

NCT04408378 | Unknown

• 1 other identifier: 69
• Study Type: observational
• Target: 156
• Locations: 1 country
• Sites: 1

Brief Summary

Morbidity, mortality and progress depends on systemic inflammation especially in ARDS patients. Previous studies claims that the proportion of mean platellet volume to platellet which can simply be determined with simple blood tests that are performed at admission, might predict the mortality in ARDS patients. Covid-19 pneumonia has a very similar clinical outlook with ARDS. Therefore we decided to research whether that proportion is legitimate for detecting the progress of Covid-19 pneumonia or not.

Conditions

Coronavirus Infection

Keywords

covid-19, MPV/PLT, pneumonia

Outcome Measures

Primary Outcomes (1)

• estimation of inflammatory changes in Covid 19 pneumonia by using MVP/PLT ratio

  İt has been studied that MPV/PLT ratio can show the cl inical couses of several diseases as well as ARDS. we thought that we can identify the coronavirus pneumonia patients earlier, at admission of hospital by using the hemogrames.

  March-May 2020

Study Arms (3)

mild pneumonia

The patients who has followed in the ward

Other: observation of covid 19 pneumonia

severe pneumonia

The patiens who has followed in the intensive care unit

Other: observation of covid 19 pneumonia

control group

patients who has not covid 19 pneumonia

Other: observation of covid 19 pneumonia

Interventions

observation of covid 19 pneumonia OTHER

We try to reveal the fact,covid-19 pneumonia prognosis can be estimated by using MPV/PLT ratio

control group; mild pneumonia; severe pneumonia

Eligibility Criteria

• Age: 18 Years - 70 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients over 18 years old who hospitalized with diagnosis of Covid-19 pneumonia between march and may 2020 in the ICU or ward.

You may qualify if:

• Patients over 18 years old who hospitalized with diagnosis of Covid-19 pneumonia between march and may 2020

You may not qualify if:

• Under 18 years old patients
• Patients with heamolytic diaseses

Sponsors & Collaborators

• Gaziosmanpasa Research and Education Hospital: lead

Study Sites (1)

Gaziosmanpaşa TREH

Istanbul, Gaziosmanpaşa, 34255, Turkey (Türkiye)

RECRUITING

Related Publications (3)

• Kim CH, Kim SJ, Lee MJ, Kwon YE, Kim YL, Park KS, Ryu HJ, Park JT, Han SH, Yoo TH, Kang SW, Oh HJ. An increase in mean platelet volume from baseline is associated with mortality in patients with severe sepsis or septic shock. PLoS One. 2015 Mar 5;10(3):e0119437. doi: 10.1371/journal.pone.0119437. eCollection 2015.

  PMID: 25742300 BACKGROUND

• Fei Y, Zhang H, Zhang C. The application of lymphocyte*platelet and mean platelet volume/platelet ratio in influenza A infection in children. J Clin Lab Anal. 2019 Nov;33(9):e22995. doi: 10.1002/jcla.22995. Epub 2019 Aug 16.

  PMID: 31420904 BACKGROUND

• Korniluk A, Koper-Lenkiewicz OM, Kaminska J, Kemona H, Dymicka-Piekarska V. Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions. Mediators Inflamm. 2019 Apr 17;2019:9213074. doi: 10.1155/2019/9213074. eCollection 2019.

  PMID: 31148950 BACKGROUND

MeSH Terms

Conditions

Coronavirus Infections; COVID-19; Pneumonia

Condition Hierarchy (Ancestors)

Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Pneumonia, Viral; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 27, 2020
• First Posted: May 29, 2020
• Study Start: June 5, 2020
• Primary Completion: July 20, 2020
• Study Completion: August 20, 2020
• Last Updated: May 29, 2020

Record last verified: 2020-05

Locations

TU (1)