Appendicitis During the National Lockdown During the COVID-19 Pandemic

NCT04407117 | Completed

• 1 other identifier: APPCOVID-19
• Study Type: observational
• Target: 6,000,000
• Locations: 1 country
• Sites: 1

Brief Summary

The study aims to examine whether a nationwide lock-down with an entire population subjugated to social distancing reduces the incidence of appendicitis. If a reduction is detected it supports the hypothesis that infectious disease may play a role in the etiology of appendicitis.

Conditions

Appendicitis

Keywords

COVID-19; Pandemic; Incidence

Outcome Measures

Primary Outcomes (1)

• Appendectomy

  Appendectomy or other surgery for appendicitis

  5 weeks

Secondary Outcomes (3)

• Postoperative length of stay

  30 days

• Mortality

  30 days

• Incidence of complicated appendicitis

  5 weeks

Interventions

Lock-down and social distancing BEHAVIORAL

Lock-down and social distancing during COVID-19 pandemic

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All persons registered in the Danish National Patient Register, i.e. all persons resident in Denmark

You may qualify if:

• Registered in the Danish National Patient Register during the study period

You may not qualify if:

• None

Sponsors & Collaborators

• Claus Anders Bertelsen, PhD, MD: lead

Study Sites (1)

Nordsjaellands Hospital

Hillerød, 3400, Denmark

Location

Related Publications (14)

• Addiss DG, Shaffer N, Fowler BS, Tauxe RV. The epidemiology of appendicitis and appendectomy in the United States. Am J Epidemiol. 1990 Nov;132(5):910-25. doi: 10.1093/oxfordjournals.aje.a115734.

  PMID: 2239906 BACKGROUND

• Bhangu A, Soreide K, Di Saverio S, Assarsson JH, Drake FT. Acute appendicitis: modern understanding of pathogenesis, diagnosis, and management. Lancet. 2015 Sep 26;386(10000):1278-1287. doi: 10.1016/S0140-6736(15)00275-5.

  PMID: 26460662 BACKGROUND

• Lamps LW. Infectious causes of appendicitis. Infect Dis Clin North Am. 2010 Dec;24(4):995-1018, ix-x. doi: 10.1016/j.idc.2010.07.012.

  PMID: 20937462 BACKGROUND

• Dzabic M, Bostrom L, Rahbar A. High prevalence of an active cytomegalovirus infection in the appendix of immunocompetent patients with acute appendicitis. Inflamm Bowel Dis. 2008 Feb;14(2):236-41. doi: 10.1002/ibd.20299.

  PMID: 17973298 BACKGROUND

• Carr NJ. The pathology of acute appendicitis. Ann Diagn Pathol. 2000 Feb;4(1):46-58. doi: 10.1016/s1092-9134(00)90011-x.

  PMID: 10684382 BACKGROUND

• Hsu YJ, Fu YW, Chin T. Seasonal variations in the occurrence of acute appendicitis and their relationship with the presence of fecaliths in children. BMC Pediatr. 2019 Nov 16;19(1):443. doi: 10.1186/s12887-019-1824-9.

  PMID: 31731890 BACKGROUND

• Wei PL, Chen CS, Keller JJ, Lin HC. Monthly variation in acute appendicitis incidence: a 10-year nationwide population-based study. J Surg Res. 2012 Dec;178(2):670-6. doi: 10.1016/j.jss.2012.06.034. Epub 2012 Jul 6.

  PMID: 22795352 BACKGROUND

• Stein GY, Rath-Wolfson L, Zeidman A, Atar E, Marcus O, Joubran S, Ram E. Sex differences in the epidemiology, seasonal variation, and trends in the management of patients with acute appendicitis. Langenbecks Arch Surg. 2012 Oct;397(7):1087-92. doi: 10.1007/s00423-012-0958-0. Epub 2012 Jun 2.

  PMID: 22661078 BACKGROUND

• Ilves I, Fagerstrom A, Herzig KH, Juvonen P, Miettinen P, Paajanen H. Seasonal variations of acute appendicitis and nonspecific abdominal pain in Finland. World J Gastroenterol. 2014 Apr 14;20(14):4037-42. doi: 10.3748/wjg.v20.i14.4037.

  PMID: 24833844 BACKGROUND

• Reinisch A, Heil J, Woeste G, Bechstein W, Liese J. The meteorological influence on seasonal alterations in the course of acute appendicitis. J Surg Res. 2017 Sep;217:137-143. doi: 10.1016/j.jss.2017.05.015. Epub 2017 May 10.

  PMID: 28599958 BACKGROUND

• Lynge E, Sandegaard JL, Rebolj M. The Danish National Patient Register. Scand J Public Health. 2011 Jul;39(7 Suppl):30-3. doi: 10.1177/1403494811401482.

  PMID: 21775347 BACKGROUND

• Pedersen CB. The Danish Civil Registration System. Scand J Public Health. 2011 Jul;39(7 Suppl):22-5. doi: 10.1177/1403494810387965.

  PMID: 21775345 BACKGROUND

• Kleif J, Thygesen LC, Gogenur I. Validity of the diagnosis of appendicitis in the Danish National Patient Register. Scand J Public Health. 2020 Feb;48(1):38-42. doi: 10.1177/1403494818761765. Epub 2018 Mar 19.

  PMID: 29554842 BACKGROUND

• Jantzen AT, Bang-Nielsen A, Bertelsen CA, Torp-Pedersen C, Kleif J. Incidence of appendicitis during COVID-19 lockdown: A nationwide population-based study. Scand J Surg. 2022 Apr-Jun;111(2):14574969221089387. doi: 10.1177/14574969221089387.

  PMID: 35488422 DERIVED

MeSH Terms

Conditions

Appendicitis; COVID-19

Interventions

Physical Distancing

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

Communicable Disease Control; Public Health Practice; Public Health; Environment and Public Health

Study Officials

• Claus A Bertelsen, PhD

  Nordsjaellands Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Associate professor, consultant surgeon

Study Record Dates

• First Submitted: May 27, 2020
• First Posted: May 29, 2020
• Study Start: March 23, 2017
• Primary Completion: April 19, 2020
• Study Completion: April 19, 2020
• Last Updated: June 19, 2020

Record last verified: 2020-06

Data Sharing

• IPD Sharing: Will not share

Locations

DK (1)