Resting Postural Tremor in Multiple Sclerosis
Spectral Analyses of Resting Postural Tremor Measured by Accelerometer and Gyroscope as a Predictive Tool of Multiple Sclerosis
1 other identifier
observational
30
1 country
3
Brief Summary
Early diagnosis is a key factor for effective treatment of multiple sclerosis. Accelerometer and gyroscope measurement of tremor could screen potential motor control dysfunction and predict a risk for development of multiple sclerosis.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started May 2021
Typical duration for all trials
3 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 20, 2020
CompletedFirst Posted
Study publicly available on registry
May 28, 2020
CompletedStudy Start
First participant enrolled
May 1, 2021
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 28, 2024
CompletedStudy Completion
Last participant's last visit for all outcomes
December 30, 2024
CompletedFebruary 6, 2024
February 1, 2024
3.5 years
May 20, 2020
February 5, 2024
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Tremor
accelerometer (1 m·s-2)
baseline
Secondary Outcomes (3)
Hand grip strength
baseline
Hand and arm function
baseline
Psychomotor processing speed
baseline
Study Arms (2)
Patients with multiple sclerosis
MS patients will be chosen by an independent neurologist.
Healthy volunteers
Healthy controls will be paired by age and sex with MS patients.
Interventions
Participants will be only examined. They will not undergo any intervention.
Eligibility Criteria
People with MS and healthy volunteers
You may qualify if:
- Group 1:
- Definite diagnosis of MS
- prevailed motor deficit of upper extremities, but without visible tremor
- stable clinical status in the preceding 3 months
- Expanded Disability Status Scale score (EDSS) ≥ 2 ≤ 7.5, and
- no corticosteroid therapy in the preceding month
- Group 2:
- Healthy volunteers in the age of 20-70 years will be employed
- There will be defined as persons without any neurological disease diagnose at the time of the measurement.
You may not qualify if:
- Patients with factors disturbing mobility (e.g. stroke, pregnancy, fractures) were excluded from the study.
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (3)
Department of neurology
Prague, 100 00, Czechia
Kamila Řasová
Prague, 128 00, Czechia
Deparment of revmatology and rehabilitation
Prague, 140 59, Czechia
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Kamila Řasová, Ph.D.
Third Faculty of Mecicine, Charles Univerzity
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- associate professor PhDr. Kamila Řasová, Ph.D.
Study Record Dates
First Submitted
May 20, 2020
First Posted
May 28, 2020
Study Start
May 1, 2021
Primary Completion
October 28, 2024
Study Completion
December 30, 2024
Last Updated
February 6, 2024
Record last verified: 2024-02
Data Sharing
- IPD Sharing
- Will not share