Endoscopic Ultrasound-Guided Celiac Plexus Neurolysis (EUS-CPN) for Chronic Pancreatitis

NCT04403074 | Recruiting

• 1 other identifier: 1708591420
• Study Type: observational
• Target: 35
• Locations: 1 country
• Sites: 1

Brief Summary

Physicians need a tracking system for specific treatment modalities, and data to determine the impact of endoscopic ultrasound pain management for patients with chronic pancreatitis.

Conditions

Chronic Pancreatitis

Keywords

Pancreatitis; Indiana; Block; Celiac; Plexus

Outcome Measures

Primary Outcomes (3)

• Use of Pain medication

  Use of pain medication (by using morphine equivalents) for each patient will be tracked weekly for up to 24 weeks post CPN to track pain management/relief for the of patients. There should be a lessening in use of pain medication as time progesses.

  Immediately post procedure & weekly up to 24 weeks

• Patient's pain intensity score (numeric pain rating scale using the visual analogue scale VAS from 1-10) will be assessed weekly (via phone call follow ups) starting right after CPN and continuing for 24 weeks.

  Compare weekly pain intensity score for pain management/relief of patients.

  Immediately post procedure and weekly up to 24 weeks

• Dosage of pain medication

  Compare dose of pain medication post procedure \& weekly for up to 24 weeks after converting all to morphine equivalents

  Immediately post procedure and weekly up to 24 weeks

Study Arms (1)

Chronic Pancreatitis Patients

Patients that have Chronic Pancreatitis and the current treatment with Celiac Plexus Blocks (CPB) are providing minimal relief of pain (CPB provide less than one month of pain relief). These patient will then receive a Celiac Plexus Neurolysis.

Procedure: Celiac Plexus Neurolysis

Interventions

Celiac Plexus Neurolysis PROCEDURE

When CPBs are not effective (less than one month of relief) then a Celiac Plexus Neurolysis may be completed to manage pain associated with Chronic Pancreatitis.

Chronic Pancreatitis Patients

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

As long as patients fall under the inclusion criteria and do not fall under exclusions, every patient can be considered. Patient must be declared safe to undergo procedure on individual basis from an evaluation from head doctor on study.

You may qualify if:

• years of age or older
• Referral for the treatment of pain related to chronic pancreatitis

You may not qualify if:

• Less than 18 years of age
• Absence of chronic pancreatitis

Sponsors & Collaborators

• Indiana University: lead

Study Sites (1)

Indiana University Hospital

Indianapolis, Indiana, 46202, United States

RECRUITING

MeSH Terms

Conditions

Pancreatitis, Chronic; Pancreatitis; Bites and Stings; Celiac Disease

Condition Hierarchy (Ancestors)

Pancreatic Diseases; Digestive System Diseases; Chronic Disease; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Poisoning; Chemically-Induced Disorders; Wounds and Injuries; Malabsorption Syndromes; Intestinal Diseases; Gastrointestinal Diseases; Metabolic Diseases; Nutritional and Metabolic Diseases

Study Officials

• Mo A, MD

  Indiana University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Mohammad Al-Haddad

CONTACT

3179440980; moalhadd@iu.edu

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor of Medicine, Associate Clinical Director

Study Record Dates

• First Submitted: October 10, 2018
• First Posted: May 27, 2020
• Study Start: October 20, 2017
• Primary Completion (Estimated): October 20, 2029
• Study Completion (Estimated): October 20, 2029
• Last Updated: February 18, 2026

Record last verified: 2026-02

Locations

US (1)