Recovery of Patients From COVID-19 After Critical Illness
The Coronavirus Disease 2019 - Recovery Study
1 other identifier
observational
536
1 country
29
Brief Summary
Patients who are critically ill with COVID-19 requiring life support in an intensive care unit (ICU) have increased risk of morbidity and mortality. Currently the ICU community does not know what effect the disease, the ICU admission, physiotherapy interventions and life support have on their long-term quality of life and whether they can return to their pre-illness level of function following ICU. COVID-Recovery will describe the physiotherapy interventions delivered to critically ill patients with COVID-19. In survivors, COVID-Recovery will utilise telephone follow-up of ICU survivors to assess disability-free survival and quality of life at 6 months after ICU admission. Additionally, COVID-Recovery will identify if there are predictors of disability-free survival. COVID-Recovery will aim to select up to 300 patients diagnosed with COVID-19 from ICUs in Australia. If they survive to hospital discharge, patients will be invited to receive a telephone questionnaire at 6 months after the ICU admission that aims to assess their long-term outcomes, including physical, cognitive and emotional function, quality of life, and whether they have been able to return to work following ICU discharge. To describe the experience of critical illness in survivors of COVID-19 and their family members. To explore and describe functional recovery, respiratory system function and respiratory health morbidity up to 6 months after ICU admission in persistently critically ill adults with COVID-19
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Jul 2020
Typical duration for all trials
29 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
May 7, 2020
CompletedFirst Posted
Study publicly available on registry
May 26, 2020
CompletedStudy Start
First participant enrolled
July 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
July 30, 2022
CompletedStudy Completion
Last participant's last visit for all outcomes
July 30, 2022
CompletedSeptember 28, 2022
September 1, 2022
2.1 years
May 7, 2020
September 26, 2022
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Disability-free survival
a composite measure of WHODAS 2.0 - 12 level and hospital survival
6 months
Physiotherapy intervention
The physiotherapy interventions provided to patients with COVID-19 admitted to the ICU and health outcomes
During the ICU stay until 3 months
Secondary Outcomes (11)
Health status
6 months
Global function
6 months
Cognitive function
6 months
Anxiety and depression
6 months
Screening for post-traumatic distress
6 months
- +6 more secondary outcomes
Eligibility Criteria
Critically ill patients with COVID-19 admitted to an intensive care unit
You may qualify if:
- COVID-19 patients who have been admitted to ICU for \> 24 hours
- Patients aged over 17 years
- Persistent critical illness cohort
- As above
- An ICU admission of at least 10 consecutive days
You may not qualify if:
- Previous enrolment in this study in a prior ICU admission
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (29)
Canberra Hospital
Garran, Australian Capital Territory, 2605, Australia
Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia
Concord Hospital
Concord, New South Wales, 2139, Australia
St Vincent's Hospital Sydney
Darlinghurst, New South Wales, 2010, Australia
Nepean Hospital
Kingswood, New South Wales, 2747, Australia
St George Hospital
Kogarah, New South Wales, 2217, Australia
John Hunter Hospital
New Lambton Heights, New South Wales, 2305, Australia
Royal North Shore Hospital
Saint Leonards, New South Wales, 2065, Australia
Westmead Hospital
Westmead, New South Wales, 2145, Australia
The Prince Charles Hospital
Chermside, Queensland, 4032, Australia
Royal Brisbane and Women's Hospital
Herston, Queensland, 4029, Australia
Redcliffe Hospital
Redcliffe, Queensland, 4020, Australia
Gold Coast Hospital
Southport, Queensland, 4215, Australia
Princess Alexandra Hospital
Woolloongabba, Queensland, 4102, Australia
Royal Adelaide Hospital
Adelaide, South Australia, 5000, Australia
Launceston Hospital
Launceston, Tasmania, 7250, Australia
Casey Hospital
Berwick, Victoria, 3806, Australia
Box Hill Hospital (Eastern Health)
Box Hill, Victoria, 3128, Australia
Monash Medical Centre
Clayton, Victoria, 3168, Australia
Dandenong Hospital
Dandenong, Victoria, 3175, Australia
St Vincent's Hospital Melbourne
Fitzroy, Victoria, 3065, Australia
Footscray Hospital
Footscray, Victoria, 3011, Australia
Frankston Hospital
Frankston, Victoria, 3199, Australia
Austin Hospital
Heidelberg, Victoria, 3084, Australia
Cabrini Health
Malvern, Victoria, 3144, Australia
Australian New Zealand Intensive Care Research Centre
Melbourne, Victoria, 3004, Australia
Royal Melbourne Hospital
Parkville, Victoria, 3050, Australia
Alfred Hospital
Prahran, Victoria, 3004, Australia
Sunshine Hospital
St Albans, Victoria, 3021, Australia
Related Publications (2)
Hodgson CL, Higgins AM, Bailey MJ, Mather AM, Beach L, Bellomo R, Bissett B, Boden IJ, Bradley S, Burrell A, Cooper DJ, Fulcher BJ, Haines KJ, Hodgson IT, Hopkins J, Jones AYM, Lane S, Lawrence D, van der Lee L, Liacos J, Linke NJ, Gomes LM, Nickels M, Ntoumenopoulos G, Myles PS, Patman S, Paton M, Pound G, Rai S, Rix A, Rollinson TC, Tipping CJ, Thomas P, Trapani T, Udy AA, Whitehead C, Anderson S, Neto AS; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. Comparison of 6-Month Outcomes of Survivors of COVID-19 versus Non-COVID-19 Critical Illness. Am J Respir Crit Care Med. 2022 May 15;205(10):1159-1168. doi: 10.1164/rccm.202110-2335OC.
PMID: 35258437DERIVEDHodgson CL, Higgins AM, Bailey MJ, Mather AM, Beach L, Bellomo R, Bissett B, Boden IJ, Bradley S, Burrell A, Cooper DJ, Fulcher BJ, Haines KJ, Hopkins J, Jones AYM, Lane S, Lawrence D, van der Lee L, Liacos J, Linke NJ, Gomes LM, Nickels M, Ntoumenopoulos G, Myles PS, Patman S, Paton M, Pound G, Rai S, Rix A, Rollinson TC, Sivasuthan J, Tipping CJ, Thomas P, Trapani T, Udy AA, Whitehead C, Hodgson IT, Anderson S, Neto AS; COVID-Recovery Study Investigators and the ANZICS Clinical Trials Group. The impact of COVID-19 critical illness on new disability, functional outcomes and return to work at 6 months: a prospective cohort study. Crit Care. 2021 Nov 8;25(1):382. doi: 10.1186/s13054-021-03794-0.
PMID: 34749756DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- PRINCIPAL INVESTIGATOR
Carol Hodgson, PhD
Monash University
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
May 7, 2020
First Posted
May 26, 2020
Study Start
July 1, 2020
Primary Completion
July 30, 2022
Study Completion
July 30, 2022
Last Updated
September 28, 2022
Record last verified: 2022-09
Data Sharing
- IPD Sharing
- Will share
- Shared Documents
- STUDY PROTOCOL, SAP, ICF, CSR, ANALYTIC CODE
- Time Frame
- 12 months after completion of the study for 12 months
- Access Criteria
- Email the Chief Investigator
IPD will be shared if approved by the steering committee and with ethical approvals.