Clinical, Biological and Histological Pulmonary and Renal Damage Associated With the SARS-CoV-2 Syndrome in Patients Admitted in ICU

NCT04385004 | Unknown

• 1 other identifier: 7815
• Study Type: observational
• Target: 320
• Locations: 1 country
• Sites: 1

Brief Summary

Renal damage in patients hospitalized for ARDS in the ICU can also be related to multiple causes including, but not limited to, the consequences of hemodynamic fluctuations in these patients or the use of nephrotoxic drugs responsible for acute post-ischemic or toxic tubular necrosis. Frequently observed abnormalities of cioagumation may also have a potential impact on renal structures, particularly glomerular capillaries. The researchers wish to characterize and phenotype the renal impairment of patients hospitalized in intensive care with tables of severe Covid19 infections in ARDS: clinical, biological and histological (by performing post-mortem biopsies). Translated with www.DeepL.com/Translator (free version)

Conditions

Acute Respiratory Distress Syndrome

Keywords

ARDS; Covid-19; SARS-CoV-2; Inflammatory cytokine; Sepsis; ICU; Tbular necrosis; Ischemia; Pulmonary damage; Renal damage; Kidney damage

Outcome Measures

Primary Outcomes (1)

• Analysis of Clinical, Biological and Histological Pulmonary and Renal Impairment Related to SARS-CoV-2

  1 month

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients diagnosed Covid-19 by RT PCR

You may qualify if:

• Patients over 18 years of age
• Diagnosed Covid-19 by RT PCR
• Hospitalized in intensive care for management of complications related to Covid-19 from March 1, 2020 to April 20, 2020
• Patient not having expressed his or her opposition, after information, to the re-use of his or her data for the purposes of this research.

You may not qualify if:

• \- Subject who expressed opposition to participating in the study

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service Reanimation Medicale

Strasbourg, 67091, France

RECRUITING

Related Publications (1)

• Beloncle F, Studer A, Seegers V, Richard JC, Desprez C, Fage N, Merdji H, Pavlovsky B, Helms J, Cunat S, Mortaza S, Demiselle J, Brochard L, Mercat A, Meziani F. Longitudinal changes in compliance, oxygenation and ventilatory ratio in COVID-19 versus non-COVID-19 pulmonary acute respiratory distress syndrome. Crit Care. 2021 Jul 15;25(1):248. doi: 10.1186/s13054-021-03665-8.

  PMID: 34266454 DERIVED

MeSH Terms

Conditions

Respiratory Distress Syndrome; COVID-19; Sepsis; Ischemia

Condition Hierarchy (Ancestors)

Lung Diseases; Respiratory Tract Diseases; Respiration Disorders; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Systemic Inflammatory Response Syndrome; Inflammation; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Ferhat MEZIANI, MD, PhD

CONTACT

33 3 69 55 10 24; ferhat.meziani@chru-strasbourg.fr

Saïd CHAYER, PhD, HDR

CONTACT

33 3 88 11 66 90; said.chayer@chru-strasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 8, 2020
• First Posted: May 12, 2020
• Study Start: April 27, 2020
• Primary Completion: July 1, 2020
• Study Completion: July 1, 2020
• Last Updated: May 28, 2020

Record last verified: 2020-05

Locations

FR (1)