NCT04379297

Brief Summary

CON-VINCE (COvid-19 National survey for assessing VIral spread by Non-affected CarriErs) is a national, monocentric, and longitudinal study aiming to evaluate the spread dynamics of the COVID-19 disease within the Luxembourgish population. Participants who are clinically asymptomatic or present with only mild symptoms will be followed up longitudinally, regularly tested for SARS-CoV-2 by RT-PCR, antibody status, and subjected to an epidemiological, clinical and biological phenotyping to better understand the nature, dynamics of infectivity and spread of the virus in the population. CON-VINCE will also track the psychological and socio-economic impact of long-term containment measures on the general population.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,870

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Apr 2020

Typical duration for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 10, 2020

Completed
26 days until next milestone

First Submitted

Initial submission to the registry

May 6, 2020

Completed
1 day until next milestone

First Posted

Study publicly available on registry

May 7, 2020

Completed
1.1 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 10, 2021

Completed
1.3 years until next milestone

Study Completion

Last participant's last visit for all outcomes

September 30, 2022

Completed
Last Updated

August 14, 2024

Status Verified

August 1, 2024

Enrollment Period

1.2 years

First QC Date

May 6, 2020

Last Update Submit

August 12, 2024

Conditions

COVID19

Keywords

CoronavirusCOVIDPrevalence

Outcome Measures

Primary Outcomes (2)

  • Prevalence and dynamics of the SARS-COV 2 infection in Luxemburg

    Evaluation of the prevalence by RT-PCR and serology testing

    04.2020-05.2021

  • Collection of samples for research

    Samples will be analysed and stored for future research

    04.2020-05.2021

Secondary Outcomes (1)

  • Psycho-social evaluation

    04.2020-05.2021

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodProbability Sample
Study Population

Representative panel of the Luxembourgish population

You may qualify if:

  • Subjects aged 18 and older of both genders, with a full capacity of consent.
  • SARS-CoV-2-positive individuals with an asymptomatic or oligosymptomatic infection (mild or oligosymptomatic disease course is defined as absence of fever and respiratory distress or cough not attributable to other known chronic disease).
  • OR post-infectious SARS-CoV-2-negative individuals with acquired immunity to SARS-CoV-2 and a mild disease course.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Luxembourg Institute of Health

Strassen, 1445, Luxembourg

Location

Related Publications (2)

  • Tsurkalenko O, Bulaev D, O'Sullivan MP, Snoeck C, Ghosh S, Kolodkin A, Rommes B, Gawron P, Rauschenberger A, Moreno CV, Gomes CPC, Kaysen A, Ohnmacht J, Schroder VE, Pavelka L, Meyers GR, Pauly L, Pauly C, Hanff AM, Meyrath M, Leist A, Sandt E, Aguayo GA, Perquin M, Gantenbein M, Abdelrahman T, Klucken J, Satagopam V, Hilger C, Turner J, Vaillant M, Fritz JV, Ollert M, Kruger R; CON-VINCE consortium and the ORCHESTRA working group. Creation of a pandemic memory by tracing COVID-19 infections and immunity in Luxembourg (CON-VINCE). BMC Infect Dis. 2024 Feb 9;24(1):179. doi: 10.1186/s12879-024-09055-z.

    PMID: 38336649RESULT

  • Ribeiro F, Schroder VE, Kruger R, Leist AK; CON-VINCE Consortium. The evolution and social determinants of mental health during the first wave of the COVID-19 outbreak in Luxembourg. Psychiatry Res. 2021 Sep;303:114090. doi: 10.1016/j.psychres.2021.114090. Epub 2021 Jun 30.

    PMID: 34247057RESULT

Biospecimen

Retention: SAMPLES WITH DNA

Naso-pharyngeal swab, Oro-pharyngeal swab, Blood, sputum,Stool

MeSH Terms

Conditions

COVID-19Coronavirus Infections

Condition Hierarchy (Ancestors)

Pneumonia, ViralPneumoniaRespiratory Tract InfectionsInfectionsVirus DiseasesCoronaviridae InfectionsNidovirales InfectionsRNA Virus InfectionsLung DiseasesRespiratory Tract Diseases

Study Officials

  • Rejko Krüger, Dr

    Luxembourg Institute of Health

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

May 6, 2020

First Posted

May 7, 2020

Study Start

April 10, 2020

Primary Completion

June 10, 2021

Study Completion

September 30, 2022

Last Updated

August 14, 2024

Record last verified: 2024-08

Locations

LU(1)