Haemoglobin Concentration on COVID-19

NCT04377607 | Unknown

• 1 other identifier: 145/2020
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

A rapid oxygen desaturation has observed in patients with COVID-19 which have seriously respiratory failure and most of them have intubated and connected to the mechanical ventilator. Finally, many of them have died during the process. ORF8 and superficial glycoproteins of a novel coronavirus bind to porphyrin on haemoglobin molecules and inhibit heme metabolism in an erythrocyte. However, it is not clarify the effects of the novel coronavirus on mean corpuscular volume (MCV), mean corpuscular of haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC).

Conditions

Corona Virus Infection

Keywords

coronavirus; haemoglobin concentration; COVID-19; severity of disease

Outcome Measures

Primary Outcomes (1)

• Relationship between severity of disease and values of erythrocyte indices

  The severity of disease can decrease haemoglobin concentration and destroy oxygen transport.

  5 days

Secondary Outcomes (1)

• Sensitivity of haemoglobin concentration on severity of the disease

  5 days

Study Arms (3)

Group OP

outpatients with asymptomatic or uncomplicated or mild pneumonia

Other: File scanning

Group H

hospitalized patients

Other: File scanning

Group IC

patients admitted to intensive care unit

Other: File scanning

Interventions

File scanning OTHER

RBC, HGB, HCT, MCH, MCV, MCHC, WBC values will be noted in the hemogram test performed at the time of initial admission

Group H; Group IC; Group OP

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients who applied to the hospital for a coronavirus disease symptom and whose covid-19 test was positive

You may qualify if:

• All patients with COVID-19 test (+) using the PCR technique

You may not qualify if:

• Those receiving blood products or any drugs that will affect their blood values before admission
• Those patient with any hematologic diseases

Sponsors & Collaborators

• Nevsehir Public Hospital: lead

Study Sites (1)

Konya Training and Research Hospital

Konya, 42040, Turkey (Türkiye)

RECRUITING

MeSH Terms

Conditions

Coronavirus Infections; COVID-19

Condition Hierarchy (Ancestors)

Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Infections; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Lung Diseases; Respiratory Tract Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Specialist

Study Record Dates

• First Submitted: May 4, 2020
• First Posted: May 6, 2020
• Study Start: November 1, 2020
• Primary Completion: November 20, 2020
• Study Completion: December 30, 2020
• Last Updated: September 16, 2020

Record last verified: 2020-09

Locations

TU (1)