Hyaluronic Acid Effect on Xenogenic Bone Healing

NCT04377256 | Completed DMC

• 1 other identifier: USJ-2019-267
• Study Type: interventional
• Target: 7
• Locations: 1 country
• Sites: 2

Brief Summary

The aim of this study is to test the hyaluronic acid hydrogel impact on the healing acceleration of xenogenic bone substitutes used in ridge preservation. Following tooth extraction, bone particles are mixed with the hyaluronic acid gel and grafted in the tooth socket. at the implant placement phase, a cone beam computer assisted tomography file is recorded in order to compare it with the baseline and a biopsy to evaluate the histological consequences.

Conditions

Bone Resorption; Tooth Loss

Keywords

tooth extraction; ridge preservation; hyaluronic acid; dental implant

Outcome Measures

Primary Outcomes (2)

• Radiological assessement of the boe resorption

  the baseline if the CBCT is compared to the 4 months post-op to assess the bone resorption

  4 months

• Histomorphometric analysis

  During implant placement, a bone biopsy is harvested and stained with different colorants to assess microscopically the biological healing

  4 months

Study Arms (2)

Radiological assessement

EXPERIMENTAL

Two CBCTs were recorded and compared, one at the baseline and the other at 4 months post-op. The bone resorption was quantified and analyzed using ITK-SNAP software

Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket

Histomorphometric analysis

EXPERIMENTAL

During implant placement (4 months after the bone grafting), a bone biopsy is collected and stained with several colorants to analyze the biological bone healing

Procedure: Ridge preservation: Tooth extration and immediat bone grafting in the socket

Interventions

Ridge preservation: Tooth extration and immediat bone grafting in the socket PROCEDURE

Following the tooth extraction, the socket is filled with a mixture of xenogenic bone and hyaluronic acid and sealed with an epithelio-connective arrested from the maxillary palate

Histomorphometric analysis; Radiological assessement

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Patients in need of tooth extraction and willing to receive dental implants in the extraction site
• Presence of two mono radicular teeth in need of extraction

You may not qualify if:

• Patients with systemic diseases
• Patients under 8 years and above 60 years.
• Presence of endodontic or periodontal lesion in the extraction sites

Sponsors & Collaborators

• Saint-Joseph University: lead

Study Sites (2)

Saint-Joseph university

Beirut, Lebanon, 1104 2020, Lebanon

Location

Universte Saint Joseph-Beyrouth

Beirut, Lebanon

Location

MeSH Terms

Conditions

Bone Resorption; Tooth Loss

Condition Hierarchy (Ancestors)

Bone Diseases; Musculoskeletal Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Tooth Diseases

Study Officials

• Ronald J Younes, Phd

  Head of oral surgery department, facuty of dentistry ,Universite SainT Joseph-Beyrouth

  STUDY DIRECTOR

• Bachar A Husseini, DDS

  Department of oral surgery, facuty of dentistry ,Universite SainT Joseph-Beyrouth

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 3, 2020
• First Posted: May 6, 2020
• Study Start: May 1, 2020
• Primary Completion: January 10, 2021
• Study Completion: May 10, 2021
• Last Updated: April 3, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

LE (2)