The Effect of Norepinephrine on Cardiac Output in Patients Undergoing Liver Transplant .

NCT04376281 | Completed DMC

• 1 other identifier: MD.241-2019
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Early administration of NE in liver transplant recipient might enhance cardiac output through an increase in cardiac preload .

Conditions

Liver Transplantation

Keywords

Liver transplantaion , fluid management , noradrenaline

Outcome Measures

Primary Outcomes (1)

• The effect of Noradrenaline on change of cardiac output .

  The effect of Noradrenaline on change of cardiac output .

  along the procedure ; from skin incision to the end of surgery

Secondary Outcomes (3)

• The effect of NE on mean systemic filling pressure .

  along the procedure ; from skin incision to the end of surgery

• The effect of NE on venous return .

  along the procedure ; from skin incision to the end of surgery

• The effect of NE on central venous pressure .

  along the procedure ; from skin incision to the end of surgery

Study Arms (1)

Noradrenaline group

EXPERIMENTAL

Drug: Noradrenaline

Interventions

Noradrenaline DRUG

Noradrenaline infusion for patients undergoing liver transplantaion from living donor .

Noradrenaline group

Eligibility Criteria

• Age: 18 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may not qualify if:

• Patients less than 18 years.
• Patients undergoing liver transplantation for acute liver failure .
• All Chronic Hypertensive patients on medication , whether controlled on not controlled
• Those with high risk of post transplant renal dysfunction (serum creatinine \>1.5 mg/dL at time of transplant)

Sponsors & Collaborators

• Cairo University: lead

Study Sites (1)

kasr El Ainy school of medicine

Cairo, 11211, Egypt

Location

Related Publications (4)

• Rudnick MR, Marchi LD, Plotkin JS. Hemodynamic monitoring during liver transplantation: A state of the art review. World J Hepatol. 2015 Jun 8;7(10):1302-11. doi: 10.4254/wjh.v7.i10.1302.

  PMID: 26052376 BACKGROUND

• Moller S, Bendtsen F, Henriksen JH. Effect of volume expansion on systemic hemodynamics and central and arterial blood volume in cirrhosis. Gastroenterology. 1995 Dec;109(6):1917-25. doi: 10.1016/0016-5085(95)90759-9.

  PMID: 7498657 BACKGROUND

• Mukhtar A, Dabbous H. Modulation of splanchnic circulation: Role in perioperative management of liver transplant patients. World J Gastroenterol. 2016 Jan 28;22(4):1582-92. doi: 10.3748/wjg.v22.i4.1582.

  PMID: 26819524 BACKGROUND

• Maas JJ, Geerts BF, van den Berg PC, Pinsky MR, Jansen JR. Assessment of venous return curve and mean systemic filling pressure in postoperative cardiac surgery patients. Crit Care Med. 2009 Mar;37(3):912-8. doi: 10.1097/CCM.0b013e3181961481.

  PMID: 19237896 BACKGROUND

MeSH Terms

Interventions

Norepinephrine

Intervention Hierarchy (Ancestors)

Ethanolamines; Amino Alcohols; Alcohols; Organic Chemicals; Amines; Biogenic Monoamines; Biogenic Amines; Catecholamines; Catechols; Phenols; Benzene Derivatives; Hydrocarbons, Aromatic; Hydrocarbons, Cyclic; Hydrocarbons

Study Officials

• Ahmed M Mukhtar, MD

  professor

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: MD

Study Record Dates

• First Submitted: April 15, 2020
• First Posted: May 6, 2020
• Study Start: December 15, 2019
• Primary Completion: August 1, 2021
• Study Completion: October 1, 2021
• Last Updated: November 9, 2021

Record last verified: 2021-11

Data Sharing

• IPD Sharing: Will not share

Locations

EG (1)