co2 Gap and co2/o2 Ratio in Liver Transplant Patients

NCT03374579 | Unknown

• 1 other identifier: N-60-2017
• Study Type: interventional
• Target: 40
• Locations: 1 country
• Sites: 2

Brief Summary

finding surrogate to co to trace the effect of preload challenge would make the test more applicable without the need of advanced hemodynamic monitors,suggested that co2 gap can be used to detect FR after mini fluid challenge and fluid bolts .

Conditions

Liver Transplantation

Outcome Measures

Primary Outcomes (1)

• co2gap

  Difference between arterial and venous co2 gap

  30 minuets after fluid bolus

Secondary Outcomes (1)

• Stroke volume

  Baseline 30 minutes after Icu admission, 1 minutes after mini fluid challenge , 30 minutes after fluid bolus

Study Arms (1)

CO2 gap

EXPERIMENTAL

The patients will receive fluid bolus and observe changes in co2 gap and gap/ ratio in them.

Diagnostic Test: Fluid challenge

Interventions

Fluid challenge DIAGNOSTIC_TEST

Fluid challenge and measure change in co2 gap

CO2 gap

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• patients post liver transplantation
• serum lactate \>2mmol/L

You may not qualify if:

• age less than 18 years
• patients with fulminant liver failure.

Sponsors & Collaborators

• Kasr El Aini Hospital: lead

Study Sites (2)

Cairo University Medical School

Cairo, 11511, Egypt

RECRUITING

Kasralainy hospital

Cairo, 11562, Egypt

RECRUITING

Study Officials

• Ahmed m Mukhtar, professor

  kasrelainy medical school,cairo university,cairo,egypt

  PRINCIPAL INVESTIGATOR

• Hassan kh Nagi, professor

  kasrelainy medical school,cairo university,cairo,egypt

  STUDY CHAIR

Central Study Contacts

Ahmed m Mukhtar, Professor

CONTACT

+0220111420844; Ahmed.mukhtar@kasralainy.edu.eg

Hassan kh Nagi, Professor

CONTACT

01223634792; hknagi@hotmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Model Details: Fluid challenge with assessment of change of co2 gap

Study Record Dates

• First Submitted: December 11, 2017
• First Posted: December 15, 2017
• Study Start: June 12, 2017
• Primary Completion: May 12, 2018
• Study Completion: September 12, 2018
• Last Updated: March 29, 2018

Record last verified: 2018-03

Data Sharing

• IPD Sharing: Will not share

Locations

EG (2)