Taurine as a Possible Anti-aging Therapy?

NCT05149716 | Completed

• 1 other identifier: Taurine_aging
• Study Type: interventional
• Target: 24
• Locations: 1 country
• Sites: 1

Brief Summary

Among the strategies that can improve the body's ability to counteract oxidative stress, the use of nutritional antioxidants has been investigated. Taurine is a "semi-essential" amino acid, also called a nitrogen compound, which has been used as an effective antioxidant due to its ability to neutralize hypochlorous acid, an extremely toxic oxidant produced by leukocytes in the inflammatory process in humans.

Conditions

Oxidative Stress

Keywords

Aging; Oxidative Stress; Taurine; Nutritional Supplementation; Therapeutic Strategy

Outcome Measures

Primary Outcomes (3)

• Change from baseline in blood oxidative stress marker measurement - Superoxide Dismutase (SOD).

  The superoxide dismutase (SOD) activity in erythrocytes was evaluated by the spectrophotometric method, and were calculated at 16 weeks in comparision to the baseline.

  sixteen weeks

• Change from baseline in blood oxidative stress marker measurement - Glutathione reductase (GR).

  Glutathione reductase (GR) activity was determined by the spectrophotometric method at 37 ºC/340nm after the oxidation of NADPH in the presence of oxidized glutathione, and were calculated at 16 weeks in comparision to the baseline.

  sixteen weeks

• Change from baseline in blood oxidative stress marker measurement - Malondialdehyde (MDA).

  The malondialdehyde (MDA) were calculated at 16 weeks in comparision to the baseline.

  sixteen weeks

Study Arms (2)

Taurine supplementation

EXPERIMENTAL

Taurine supplementation composed of capsules of taurine powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks

Dietary Supplement: Taurine

Placebo supplementation

PLACEBO COMPARATOR

Placebo supplementation composed of capsules of starch powder. Dosage: 1.5 gram/day Frequency: 1 time/day Duration: 16 weeks

Dietary Supplement: Placebo

Interventions

Taurine DIETARY_SUPPLEMENT

Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 gram/day

Also known as: Taurine supplementation in capsules of 500 grams of taurine powder, total dosage: 1.5 grams/day

Taurine supplementation

Placebo DIETARY_SUPPLEMENT

Placebo supplementation in capsules of 500 grams of starch powder, total dosage: 1.5 gram/day

Placebo supplementation

Eligibility Criteria

• Age: 55 Years - 70 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Had being aged 55-70 years;
• Female;
• Post-menopausal;
• Sedentary (not practicing physical exercise for at least 6 months).

You may not qualify if:

• Chronic kidney diseases;
• Infectious contagious diseases;
• Coronary heart disease;
• Smokers
• Alcoholics.

Sponsors & Collaborators

• University of Sao Paulo: lead
• Fundação de Amparo à Pesquisa do Estado de São Paulo: collaborator
• Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.: collaborator

Study Sites (1)

Escola de Educação Física e Esporte de Ribeirão Preto

Ribeirão Preto, São Paulo, 14040-907, Brazil

Location

Related Publications (9)

• Schaffer S, Kim HW. Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomol Ther (Seoul). 2018 May 1;26(3):225-241. doi: 10.4062/biomolther.2017.251.

  PMID: 29631391 BACKGROUND

• Tadolini B, Pintus G, Pinna GG, Bennardini F, Franconi F. Effects of taurine and hypotaurine on lipid peroxidation. Biochem Biophys Res Commun. 1995 Aug 24;213(3):820-6. doi: 10.1006/bbrc.1995.2203.

  PMID: 7654243 BACKGROUND

• Oliveira MW, Minotto JB, de Oliveira MR, Zanotto-Filho A, Behr GA, Rocha RF, Moreira JC, Klamt F. Scavenging and antioxidant potential of physiological taurine concentrations against different reactive oxygen/nitrogen species. Pharmacol Rep. 2010 Jan-Feb;62(1):185-93. doi: 10.1016/s1734-1140(10)70256-5.

  PMID: 20360629 BACKGROUND

• Lourenco R, Camilo ME. Taurine: a conditionally essential amino acid in humans? An overview in health and disease. Nutr Hosp. 2002 Nov-Dec;17(6):262-70.

  PMID: 12514918 BACKGROUND

• Sun Jang J, Piao S, Cha YN, Kim C. Taurine Chloramine Activates Nrf2, Increases HO-1 Expression and Protects Cells from Death Caused by Hydrogen Peroxide. J Clin Biochem Nutr. 2009 Jul;45(1):37-43. doi: 10.3164/jcbn.08-262. Epub 2009 Jun 30.

  PMID: 19590705 BACKGROUND

• Rosa FT, Freitas EC, Deminice R, Jordao AA, Marchini JS. Oxidative stress and inflammation in obesity after taurine supplementation: a double-blind, placebo-controlled study. Eur J Nutr. 2014 Apr;53(3):823-30. doi: 10.1007/s00394-013-0586-7. Epub 2013 Sep 25.

  PMID: 24065043 BACKGROUND

• De Carvalho FG, Galan BSM, Santos PC, Pritchett K, Pfrimer K, Ferriolli E, Papoti M, Marchini JS, de Freitas EC. Taurine: A Potential Ergogenic Aid for Preventing Muscle Damage and Protein Catabolism and Decreasing Oxidative Stress Produced by Endurance Exercise. Front Physiol. 2017 Sep 20;8:710. doi: 10.3389/fphys.2017.00710. eCollection 2017.

  PMID: 28979213 BACKGROUND

• Chupel MU, Minuzzi LG, Furtado GE, Santos ML, Ferreira JP, Filaire E, Teixeira AM. Taurine supplementation reduces myeloperoxidase and matrix-metalloproteinase-9 levels and improves the effects of exercise in cognition and physical fitness in older women. Amino Acids. 2021 Mar;53(3):333-345. doi: 10.1007/s00726-021-02952-6. Epub 2021 Feb 13.

  PMID: 33586039 BACKGROUND

• Marcinkiewicz J, Kontny E. Taurine and inflammatory diseases. Amino Acids. 2014 Jan;46(1):7-20. doi: 10.1007/s00726-012-1361-4. Epub 2012 Jul 19.

  PMID: 22810731 RESULT

MeSH Terms

Interventions

Taurine

Intervention Hierarchy (Ancestors)

Alkanesulfonic Acids; Alkanes; Hydrocarbons, Acyclic; Hydrocarbons; Organic Chemicals; Sulfonic Acids; Sulfur Acids; Sulfur Compounds

Study Officials

• Ellen C Freitas, PhD

  University of Sao Paulo

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: PARTICIPANT, INVESTIGATOR
• Masking Details: Supplement capsule packages were labeled as "Supplement A" and "Supplement B" and the nutrient (taurine or placebo- starch) was revealed after the end of the intervention.
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Model Details: Double-blind placebo controlled study

Study Record Dates

• First Submitted: November 19, 2021
• First Posted: December 8, 2021
• Study Start: January 13, 2020
• Primary Completion: June 15, 2020
• Study Completion: July 3, 2020
• Last Updated: December 8, 2021

Record last verified: 2021-12

Data Sharing

• IPD Sharing: Will not share

Locations

BR (1)