NCT04372901

Brief Summary

CAD/CAM (computer aided design/ computer aided manufacturing) constructed screw retained implant supported frameworks give solutions for the problems arising from the lost wax technique by improving accuracy, adaptation and passive fit of the final restoration. However, concerns about the passive fit of a pre-implant insertion CAD/CAM constructed framework still exists due to the expected errors in imaging, registration, surgical guide construction, adaptation and hence transferring the planned position intra-orally.

Trial Health

43
At Risk

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
8

participants targeted

Target at below P25 for not_applicable

Timeline
Completed

Started May 2021

Geographic Reach
1 country

1 active site

Status
unknown

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

April 24, 2020

Completed
10 days until next milestone

First Posted

Study publicly available on registry

May 4, 2020

Completed
12 months until next milestone

Study Start

First participant enrolled

May 1, 2021

Completed
8 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2022

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

April 1, 2022

Completed
Last Updated

April 14, 2021

Status Verified

April 1, 2021

Enrollment Period

8 months

First QC Date

April 24, 2020

Last Update Submit

April 13, 2021

Conditions

Keywords

PassiveFitScrewmentedCAD/CAMFrameworks

Outcome Measures

Primary Outcomes (1)

  • Passive fit

    Evaluation of Passive fit between CAD/CAM Implant Supported Screw-retained Metal Frameworks Based on Actual Versus Screwmented Ones Based on Virtual Implant Position using one screw test .

    10 weeks

Study Arms (2)

digitally constructed frameworks before implant placement

EXPERIMENTAL

Intervention group in which the edentulous area will be restored with 3-implant screwmented CAD/CAM frameworks constructed based on planned implant positions.

Procedure: Digitally constructed frameworks before implant placement

digitally constructed frameworks after implant placement

ACTIVE COMPARATOR

Control group: edentulous area will be restored with 3-implant conventional screw retained CAD/CAM frameworks constructed after implant placement

Procedure: Digitally constructed frameworks after implant placement

Interventions

Intervention group in which the edentulous area will be restored with 3-implant screwmented CAD/CAM frameworks constructed based on planned implant positions.

digitally constructed frameworks before implant placement

Control group: edentulous area will be restored with 3-implant conventional screw retained CAD/CAM frameworks constructed after implant placement.

digitally constructed frameworks after implant placement

Eligibility Criteria

Sexall
Healthy VolunteersYes
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

  • Mandibular Kenndy Class I.
  • Opposing completely dentulous, fully or partially restored dentition.
  • Good oral hygiene.
  • The patient should have bone for implants, minimum bone height 10 mm and minimum bone diameter should be 6 mm.
  • Adequate inter arch space for restoration 15 mm or more.
  • Adult patients age ≥18 years

You may not qualify if:

  • \- . any medical disorder that could complicate surgical phase or affect osteointegration. Radiation chemotherapy.
  • ii. smokers more than 10/daily.
  • iii. Uncooperative patients.
  • iv. Patients with Para-functional habits
  • v. Patients with severe periodontal diseases.
  • vi. Patients with limited mouth opening.
  • vii. Presence of intraoral pathological lesions.
  • viii. Diabetic (HbA1c \>7.5%)

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Faculty of dentistry

Cairo, Manial, 12911, Egypt

Location

Related Publications (1)

  • de Franca DG, Morais MH, das Neves FD, Barbosa GA. Influence of CAD/CAM on the fit accuracy of implant-supported zirconia and cobalt-chromium fixed dental prostheses. J Prosthet Dent. 2015 Jan;113(1):22-8. doi: 10.1016/j.prosdent.2014.07.010. Epub 2014 Sep 30.

    PMID: 25277028BACKGROUND

MeSH Terms

Conditions

Mouth, Edentulous

Condition Hierarchy (Ancestors)

Mouth DiseasesStomatognathic DiseasesTooth Diseases

Study Officials

  • Mohamed El-Sayyed, BDS

    Teaching assistant MIU

    PRINCIPAL INVESTIGATOR
  • Mohamed ElKhashab, Phd

    Lecturer of prosthodontics, Faculty of Dentistry, Cairo Univerusty

    STUDY DIRECTOR
  • Iman Radi, Phd

    Cairo University

    STUDY DIRECTOR

Central Study Contacts

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Masking Details
The study is based on different technical procedures of fabrication of the frameworks. Since these differences are visible, the operator, the assessor and the technician involved in the study cannot be blinded. Since blinding was not possible, randomization was delayed till the prosthetic phase to avoid any performance bias in the surgical steps. But the statistician will be blinded .
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Trial design to be conducted is RCT, split mouth , two arms, and Equivalence frame with 1:1 allocation ratio.
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Master student- Oral implantology -Cairo univeristy

Study Record Dates

First Submitted

April 24, 2020

First Posted

May 4, 2020

Study Start

May 1, 2021

Primary Completion

January 1, 2022

Study Completion

April 1, 2022

Last Updated

April 14, 2021

Record last verified: 2021-04

Data Sharing

IPD Sharing
Will not share

The author of "study will publish it in an internationally acknowledged journal.

Locations