Acute Cardiovascular Events Triggered by COVID-19-Related Stress

NCT04368637 | Unknown DMC

• 1 other identifier: JCCG.JoCORE.4.4040
• Study Type: observational
• Target: 50
• Locations: 1 country
• Sites: 5

Brief Summary

The current COVID19 pandemic has afflicted almost the whole globe. The stress related to the pandemic, not the direct virus-related injury, can be potentially associated with acute cardiovascular events due to a large list of physical and psychosocial stresses. This study is a cross sectional study that will enroll patients evaluated during the COVID19 pandemic period for acute cardiovascular events.

Conditions

Acute Myocardial Infarction; Ventricular Tachycardia; Sudden Cardiac Death; Stroke, Acute

Keywords

COVID-19; triggered myocardial infarction; triggered acute cardiovascular events; COVID-19-related stress

Outcome Measures

Primary Outcomes (4)

• Acute cardiovascular event triggered by COVID-19 stress

  Acute myocardial infarction as diagnosed by ST segment elevation or depression or inverted T wave on 12-lead EKG and elevated levels of cardiac troponins above the 99% of the normal values. A. Acute MI (STEMI and NSTEMI). B. Aborted on non-aborted sudden cardiac death not attributed to a known etiology. C. Sustained or non-sustained ventricular tachy-arrhythmia not attributed to a known etiology. D. ICD shocks. 3. Absence of suspected or confirmed infection with the COVID19 virus. 4. Definite physical or psycho-social stressful trigger appearing in relation to the COVID-19 situation (lock down stress, financial stress, anger, depression, fear, sorrow, death of a significant person, eating binges, smoking binges, physical stress \[carrying walking for shopping and carrying excess weights\] ..etc) as judged by a unanimous agreement of three investigators in the steering committee.

  4 months

• Ventricular tachycardia

  Typical ventricular tachycardia on 12-lead EKG or EKG monitor.

  4 months

• acute stroke

  acute neurological symptoms of hemiparesis or dysrthria due to brain ischemia proven by computerized tomography or magnatic resonance

  4 months

• Implantable cardioverter defibrillator (ICD) shock

  Finding an episode of ventricular tachycardia on interrogation of ICD tracing

  4 months

Eligibility Criteria

• Age: 18 Years - 100 Years
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All comers to the ER reporting acute cardiovascular event as pre-specified above. The patient reporting a physical or social stress directly related to the COVID-19 pandemic such as anger, fear, death of a significant person, financial stress, eating binge, extreme physical effort, etc..

You may qualify if:

• Age \>18 years.
• Acute MI (STEMI and NSTEMI).
• Sudden cardiac death
• Ventricular tachycardia
• ICD shocks.
• Stressful trigger prior to the cardiovascular event

You may not qualify if:

• \* COVID-19 infection.

Sponsors & Collaborators

• Jordan Collaborating Cardiology Group: lead

Study Sites (5)

Istishari Hospital

Amman, 11184, Jordan

RECRUITING

Abdelhadi Hospital

Amman, Jordan

RECRUITING

Farah Hospital

Amman, Jordan

RECRUITING

Jordan Hospital

Amman, Jordan

RECRUITING

Specialty Hospital

Amman, Jordan

RECRUITING

MeSH Terms

Conditions

Tachycardia, Ventricular; Death, Sudden, Cardiac; Stroke; COVID-19

Condition Hierarchy (Ancestors)

Tachycardia; Arrhythmias, Cardiac; Heart Diseases; Cardiovascular Diseases; Cardiac Conduction System Disease; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Heart Arrest; Death, Sudden; Death; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Ayman J Hammoudeh, MD, FACC

  JCC Group

  STUDY CHAIR

Central Study Contacts

Ayman J Hammoudeh, MD, FACC

CONTACT

0096265001000; hammoudeh_ayman@yahoo.com

Ayadeh Madanat, MD

CONTACT

00962796224241; ayadeh.madanat@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Interventional Cardiologist

Study Record Dates

• First Submitted: April 26, 2020
• First Posted: April 30, 2020
• Study Start: May 3, 2020
• Primary Completion: July 30, 2020
• Study Completion: August 30, 2020
• Last Updated: May 5, 2020

Record last verified: 2020-05

Data Sharing

• IPD Sharing: Will not share

Locations

JO (5)