Lung Ultrasound to Diagnose COVID-19

NCT04368338 | Completed

• 1 other identifier: PI2020_843_0030
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Covid-19 (English acronym meaning coronavirus disease 2019) is an emerging infectious disease caused by a strain of coronavirus called SARS-CoV-2. The current pandemic has resulted in a significant number of admissions in the emergency room (ER) due to suspicion of COVID-19 infection. Use of lung ultrasound is standard practice to diagnose acute respiratory failure in ER. Recently, typical lung ultrasonographic characteristics of COVID-19 disease has been described. During the COVID-19 pandemic, the use of this tool could be of interest in order to allow an early, simple and reliable triage in patients with suspected COVID-19 infection admitted in ER. In addition, the visualization of early signs in specific areas could be a predictive marker of the severity of the disease. The objective of this project will be to study the association between the signs on lung ultrasound and the result of RT-PCR in patients with suspected COVID-19 infection in the ER.

Conditions

Covid-19; Lung Ultrasound; Respiratory Complication

Keywords

Covid-19; lung ultrasound; Respiratory Complication

Outcome Measures

Primary Outcomes (1)

• Lung ultrasound/biological correlation research modulating the severity of Covid-19 disease

  Polymerase chain reaction tests after reverse transcription for the detection of covid-19 viral RNA will be done as biological test.

  6 months

Interventions

COVID-19 RT-PCR DIAGNOSTIC_TEST

Polymerase chain reaction tests after reverse transcription for the detection of viral Covid-19 RNA (RT-PCR)

lung ultrasound PROCEDURE

lung ultrasound is standard practice to diagnose acute respiratory failure in Emergency room

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients admitted to Emergency Room (ER) for suspicion of COVID-19 infection who has a SARS-CoV-2 RT-PCR test and for whom the emergency doctor decide to perform a lung ultrasound as part of the BLUE protocol.

You may qualify if:

• patients admitted to Emergency Room for suspicion of COVID-19 infection with has a SARS-CoV-2 RT-PCR test and for whom the emergency doctor decide to perform a lung ultrasound

You may not qualify if:

• patients \< 18 years of age or under guardianship or curators,
• pregnancy
• poor echogenicity due to the presence of an acoustic barrier (pneumothorax, subcutaneous emphysema, etc.)
• patients with a suspected or proven acute lung disease (pneumonitis, acute respiratory distress syndrome (ARDS))
• chronic interstitial lung disease
• patients who will refuse to give their consent.

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

BAR

Amiens, 80054, France

Location

Related Publications (1)

• Bar S, Lecourtois A, Diouf M, Goldberg E, Bourbon C, Arnaud E, Domisse L, Dupont H, Gosset P. The association of lung ultrasound images with COVID-19 infection in an emergency room cohort. Anaesthesia. 2020 Dec;75(12):1620-1625. doi: 10.1111/anae.15175. Epub 2020 Jul 1.

  PMID: 32520406 DERIVED

MeSH Terms

Conditions

COVID-19

Interventions

COVID-19 Nucleic Acid Testing

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Intervention Hierarchy (Ancestors)

COVID-19 Testing; Clinical Laboratory Techniques; Diagnostic Techniques and Procedures; Diagnosis; Investigative Techniques

Study Officials

• Stéphane Bar, MD

  CHU Amiens

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 28, 2020
• First Posted: April 29, 2020
• Study Start: April 28, 2020
• Primary Completion: January 28, 2021
• Study Completion: July 20, 2021
• Last Updated: July 21, 2021

Record last verified: 2021-07

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)