Endurance Exercise on nrf2 mRNA Expression Gene and VO2max

NCT04366479 | Completed DMC

• 1 other identifier: HasanuddinU
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

Indonesian Hajj Health Officers have the responsibility and very important role in providing health services for Indonesian pilgrims during embarkation and debarkation. One of the main indicators of success is they have excellent physical fitness. This study aims to determine the effectiveness of an intervention program by comparing the results of (intervention) intervention groups, namely the effect of physical exercise interventions (endurance exercise) measured before and after the intervention. This research is an intervention study, and I understand that the process of taking blood can occur with fear, pain due to being pricked by a needle, can faint or be infected. However, previous blood pressure tests, sterile collection techniques and performed by experts, are very unlikely to cause side effects.

Conditions

Physical Fitness

Keywords

Endurance Exercise; Nuclear Respiratory Factor; Physical Fitness (VO2max)

Outcome Measures

Primary Outcomes (2)

• VO2max Measurement

  Aerobic capacity is also known as maximal oxygen uptake or maximum oxygen consumption (VO2max)

  5 weeks

• Measurement of mRNA NRF2 Gene Expression

  RT-PCR analyzes human RNA in the nrf2 RNA sample as the target gene and GAPDH is selected as the housekeeping gene

  5 weeks

Study Arms (1)

intervention group

EXPERIMENTAL

The study lasted for 5 weeks (1 month 7 days). During the research process, we monitor closely, especially the training schedule, implementation, and evaluation, directly and indirectly. Directly assisting participants to do endurance training activities, not directly monitoring via telephone or WhatsApp.

Behavioral: Multistage Fitness Test

Interventions

Multistage Fitness Test BEHAVIORAL

Participants only joined in one group will be given intervention for 5 weeks in the form of running 1600 meters duration of 20-30 minutes 3 times a week. It is important for the participants as well as for us to know which training methods are given. this information will be documented in our file, but we will not see these files until after the research is complete. this is the best way we have for testing without being influenced by what we think or expect might happen.

intervention group

Eligibility Criteria

• Age: 30 Years - 39 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Participants from the Nurse profession aged 30 - 39 years
• Pass the selection of candidates for Indonesian Hajj Health Officers
• Understand the physical training program instructions in the rockport method
• Willing to participate in activities and all research provisions

You may not qualify if:

• Had a history of coronary heart disease,asthma
• Not approved by the doctor to participate in the study due to a medical condition

Sponsors & Collaborators

• Hasanuddin University: lead
• Indonesia-MoH: collaborator

Study Sites (1)

Makassar Center for Health Training

Makassar, South Sulawesi, 90245, Indonesia

Location

Related Publications (3)

• Vivian H. Heyward. (2016). Aerobic Capacity, Physical Fitness and VO2 Maxium Measurement. Advance Fitness Assessment & Exercise Prescription, 252(805), 2-5. https://www.biopac.com/wp-content/uploads/app252.pdf

  RESULT

• Lockie RG, Dawes JJ, Moreno MR, Cesario KA, Balfany K, Stierli M, Dulla JM, Orr RM. Relationship Between the 20-m Multistage Fitness Test and 2.4-km Run in Law Enforcement Recruits. J Strength Cond Res. 2021 Oct 1;35(10):2756-2761. doi: 10.1519/JSC.0000000000003217.

  PMID: 31268997 RESULT

• Zhao XQ, Zhang YF, Xia YF, Zhou ZM, Cao YQ. Promoter demethylation of nuclear factor-erythroid 2-related factor 2 gene in drug-resistant colon cancer cells. Oncol Lett. 2015 Sep;10(3):1287-1292. doi: 10.3892/ol.2015.3468. Epub 2015 Jul 8.

  PMID: 26622665 RESULT

Study Officials

• Mochammad Hatta, Profesor

  Department of Biomolecular Medicine, Hasanuddin University Makassar

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SUPPORTIVE CARE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: This type of quasi-experimental research (quasy experiment) with pre-test and post-test research design with only control design.

Study Record Dates

• First Submitted: April 17, 2020
• First Posted: April 29, 2020
• Study Start: May 8, 2019
• Primary Completion: October 8, 2019
• Study Completion: October 8, 2019
• Last Updated: April 30, 2020

Record last verified: 2020-04

Data Sharing

• IPD Sharing: Will not share

Locations

ID (1)