Multicenter, Retrospective Study of the Effects of Remdesivir in the Treatment of Severe Covid-19 Infections

NCT04365725 | Completed

• 1 other identifier: APHP200522
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a retrospective cohort trial to assess the efficacy of remdesivir in hospitalized adult patients diagnosed with COVID-19. The study is a multicenter trial which will be carried out on different sites in France. This trial is retrospective and will analyze the data collected during treatment.

Conditions

COVID-19

Keywords

COVID-19; Remdesivir

Outcome Measures

Primary Outcomes (1)

• Clinical course on Day 15.

  Study the prognostic factors of the clinical course of patients on Day 15 under treatment with remdesivir. Clinical progress will be categorized using a 7-point ordinal scale.

  15 days

Secondary Outcomes (9)

• Clinical course on Day 3.

  3 days

• Clinical course on Day 8

  8 days

• Clinical course on Day 11.

  11 days

• Clinical course on Day 29.

  29 days

• Duration of treatment

  29 days

Interventions

Remdesivir DRUG

Compassionate provision

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult hospital patients diagnosed with COVID-19

You may qualify if:

• Adult ≥ 18 years old.
• SARS-CoV-2 infection confirmed.
• Hospitalized patients who received at least one administration of remdesivir therapy outside of clinical trials

You may not qualify if:

• Patients included in a clinical trial testing remdesivir as an investigational drug.

Sponsors & Collaborators

• URC-CIC Paris Descartes Necker Cochin: collaborator
• Assistance Publique - Hôpitaux de Paris: lead

Study Sites (1)

Hôpital Cochin

Paris, 75014, France

Location

Related Publications (23)

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MeSH Terms

Conditions

COVID-19

Interventions

remdesivir

Condition Hierarchy (Ancestors)

Pneumonia, Viral; Pneumonia; Respiratory Tract Infections; Infections; Virus Diseases; Coronavirus Infections; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Jérémie ZERBIT, PharmaD

  Assistance Publique - Hôpitaux de Paris

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 25, 2020
• First Posted: April 28, 2020
• Study Start: May 5, 2020
• Primary Completion: June 12, 2020
• Study Completion: June 12, 2020
• Last Updated: March 9, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)