Review of Isolated Hypoganglionosis and Presentation of a New Case Complicated With Sigmoid Volvulus

NCT04363125 | Completed

• 1 other identifier: 23042020
• Study Type: observational
• Target: 310
• Locations: 1 country
• Sites: 1

Brief Summary

Isolated hypoganglionosis is rare and constitutes 3-5% of all congenital neurological bowel diseases. Since hypoganglionosis is associated with symptoms such as chronic constipation or pseudo-obstruction, it can be confused with Hirschprung's disease and it is important to make a differential diagnosis before treatment. Our aim in this study; In addition to sharing the rarely isolated hypoganglionosis and sigmoid volvulus in a 45-year-old male patient with mental retardation, the investigators present a systematic comprehensive review of hypoganglionosis.

Conditions

Pathology; Sigmoid Volvulus; Hypoganglionosis

Keywords

colon; constipation; derotation; obstruction; Hypoganglionosis; intestinal neuronal dysplasia

Outcome Measures

Primary Outcomes (1)

• Mortality

  Mortality of sigmoid volvulus due to isolated hypoganglionosis

  three months

Interventions

Pathology result DIAGNOSTIC_TEST

Pathology result of rectal biopsy

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

our case of isolated hypoganglionosis and published isolated hypoganglionosis studies patients.

You may qualify if:

• isolated hypoganglionosis
• our case of isolated hypoganglionosis

You may not qualify if:

• hypoganglionosis with Hirschsprung's disease

Sponsors & Collaborators

• Dr. Ersin Arslan Education and Training Hospital: lead
• Inonu University: collaborator

Study Sites (1)

Dr. Ersin Arslan Training and Resource Hospital

Gaziantep, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Constipation; Bites and Stings

Condition Hierarchy (Ancestors)

Signs and Symptoms, Digestive; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Poisoning; Chemically-Induced Disorders; Wounds and Injuries

Study Officials

• ufuk uylas, Specialist

  Dr. Ersin Arslan Training and Resource Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: OTHER
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 23, 2020
• First Posted: April 27, 2020
• Study Start: January 1, 2019
• Primary Completion: April 1, 2020
• Study Completion: April 20, 2020
• Last Updated: April 28, 2020

Record last verified: 2020-04

Locations

TU (1)