Impact of COVID-19 Infection on the Incidence of Ventilator-acquired Infections

NCT04359693 | Completed

• 2 other identifiers: 2020_272020-A00995-34
• Study Type: observational
• Target: 1,576
• Locations: 1 country
• Sites: 1

Brief Summary

Observational cohort study aiming at comparing the incidence of ventilator-associated lower respiratory tract infections between COVID-19 patients and two control groups: one with influenza pneumonia and the other with no viral pneumonia.

Conditions

SARS-CoV 2

Outcome Measures

Primary Outcomes (1)

• Cumulative incidence of ventilator-associated lower respiratory tract infection

  the incidence of ventilator associated pneumonia and ventilator associated tracheobronchitis

  from day 3 of mechanical ventilation to extubation or day 28 post-intubation.

Secondary Outcomes (7)

• Cumulative incidence of ventilator-associated tracheobronchitis

  from day 3 of mechanical ventilation to extubation or day 28 post intubation

• Cumulative incidence of ventilator-associated pneumonia

  from Day 3 of mechanical ventilation to extubation or day 28 post intubation.

• the cumulative incidence of ICU acquired bacteremia diagnosed

  from ICU admission to extubation or Day 28.

• ICU mortality

  at day 28

• Mortality

  at day 28

Study Arms (3)

SARS-CoV2 group

Patients receiving invasive mechanical ventilation for more than 48h with SARS-CoV-2 infection

Flu group

Patients receiving invasive mechanical ventilation for more than 48h with influenza infection

No viral infection group

Patients receiving invasive mechanical ventilation for more than 48h with no viral infection at ICU admission

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

patients suspected of pulmonary infection and admitted in ICU

You may qualify if:

• For all three groups:
• Major patient
• In patients in ICU
• Patients intubated and mechanically ventilated for more than 48 hours.
• For the SARS-CoV2 group: community-acquired SARS-CoV2 pneumonia For the influenza group: community-acquired influenza pneumonia For the "No Viral Infection" group: no viral pneumonia on admission.

You may not qualify if:

• Refusal to participate
• Lack of social security coverage

Sponsors & Collaborators

• University Hospital, Lille: lead

Study Sites (1)

Hôpital Roger Salengro, ICU, CHU Lille

Lille, 59037, France

Location

Related Publications (4)

• Kreitmann L, Bayon C, Martin-Loeches I, Povoa P, Salluh J, Rouze A, Moreau AS, Duhamel A, Labreuche J, Nseir S; Type of iMmunosuppression and the Incidence, Microbiology, and OutcomeS of ventilator-Associated lower respiratory tract infections (MIMOSA) Study Group. Association Between Type of Immunosuppression and the Incidence, Microbiology, and Outcomes of Bacterial Ventilator-Associated Lower Respiratory Tract Infections: A Retrospective Multicenter Study. Crit Care Med. 2025 May 1;53(5):e1080-e1094. doi: 10.1097/CCM.0000000000006615. Epub 2025 Feb 21.

  PMID: 39982132 RESULT

• Rouze A, Lemaitre E, Martin-Loeches I, Povoa P, Diaz E, Nyga R, Torres A, Metzelard M, Du Cheyron D, Lambiotte F, Tamion F, Labruyere M, Boulle Geronimi C, Luyt CE, Nyunga M, Pouly O, Thille AW, Megarbane B, Saade A, Magira E, Llitjos JF, Ioannidou I, Pierre A, Reignier J, Garot D, Kreitmann L, Baudel JL, Voiriot G, Plantefeve G, Morawiec E, Asfar P, Boyer A, Mekontso-Dessap A, Makris D, Vinsonneau C, Floch PE, Marois C, Ceccato A, Artigas A, Gaudet A, Nora D, Cornu M, Duhamel A, Labreuche J, Nseir S; coVAPid study group. Invasive pulmonary aspergillosis among intubated patients with SARS-CoV-2 or influenza pneumonia: a European multicenter comparative cohort study. Crit Care. 2022 Jan 4;26(1):11. doi: 10.1186/s13054-021-03874-1.

  PMID: 34983611 DERIVED

• Rouze A, Martin-Loeches I, Povoa P, Metzelard M, Du Cheyron D, Lambiotte F, Tamion F, Labruyere M, Boulle Geronimi C, Nieszkowska A, Nyunga M, Pouly O, Thille AW, Megarbane B, Saade A, Diaz E, Magira E, Llitjos JF, Cilloniz C, Ioannidou I, Pierre A, Reignier J, Garot D, Kreitmann L, Baudel JL, Fartoukh M, Plantefeve G, Beurton A, Asfar P, Boyer A, Mekontso-Dessap A, Makris D, Vinsonneau C, Floch PE, Weiss N, Ceccato A, Artigas A, Bouchereau M, Duhamel A, Labreuche J, Nseir S; coVAPid Study Group. Early Bacterial Identification among Intubated Patients with COVID-19 or Influenza Pneumonia: A European Multicenter Comparative Clinical Trial. Am J Respir Crit Care Med. 2021 Sep 1;204(5):546-556. doi: 10.1164/rccm.202101-0030OC.

  PMID: 34038699 DERIVED

• Nseir S, Martin-Loeches I, Povoa P, Metzelard M, Du Cheyron D, Lambiotte F, Tamion F, Labruyere M, Makris D, Boulle Geronimi C, Pinetonde Chambrun M, Nyunga M, Pouly O, Megarbane B, Saade A, Goma G, Magira E, Llitjos JF, Torres A, Ioannidou I, Pierre A, Coelho L, Reignier J, Garot D, Kreitmann L, Baudel JL, Voiriot G, Contou D, Beurton A, Asfar P, Boyer A, Thille AW, Mekontso-Dessap A, Tsolaki V, Vinsonneau C, Floch PE, Le Guennec L, Ceccato A, Artigas A, Bouchereau M, Labreuche J, Duhamel A, Rouze A; coVAPid study group. Relationship between ventilator-associated pneumonia and mortality in COVID-19 patients: a planned ancillary analysis of the coVAPid cohort. Crit Care. 2021 May 25;25(1):177. doi: 10.1186/s13054-021-03588-4.

  PMID: 34034777 DERIVED

Study Officials

• Saad Nseir, MD,PhD

  University Hospital, Lille

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2020
• First Posted: April 24, 2020
• Study Start: April 22, 2020
• Primary Completion: July 1, 2020
• Study Completion: July 1, 2020
• Last Updated: April 22, 2026

Record last verified: 2020-07

Locations

FR (1)