Different PEEP Settings of COVID-19 Induced ARDS
Avoiding High PEEP in COVID-19 Induced ARDS: a Multi-center Study
1 other identifier
interventional
20
1 country
1
Brief Summary
This was a multi-center prospective study. All consecutive severe cases of COVID-19 whose PO2/FiO2\<300mmHg with invasive ventilation admitted to 5 fixed-point receive COVID-19 patients hospitals in Wuhan from 5 March to 15 March 2020 were included. Epidemiological, clinical data, lung mechanics, artery blood gas test and hemodynamics at three methods to titrate PEEP, optimizing oxygenation, optimizing compliance, ARDSnet. The study was approved by the Ethics Committee of Zhongda Hsopital, Southeast University.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable covid19
Started Mar 2020
Shorter than P25 for not_applicable covid19
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
March 5, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 25, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
March 25, 2020
CompletedFirst Submitted
Initial submission to the registry
April 13, 2020
CompletedFirst Posted
Study publicly available on registry
April 24, 2020
CompletedApril 24, 2020
April 1, 2020
20 days
April 13, 2020
April 21, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Respiratory system compliance improvement
the respiratory system compliance was compared among three groups
20 minutes
Secondary Outcomes (1)
Gas echanges improvement
20 minutes
Other Outcomes (1)
hemodynamics improvement
20 minutes
Study Arms (3)
Optimizing oxygenation
EXPERIMENTALBest oxygenation during PEEP titration
Optimizing compliance
EXPERIMENTALBest compliance during PEEP titration
ARDSnet
EXPERIMENTALPEEP settings according to ARDSnet table
Interventions
Gas exchanges measurement at different PEEP
lung mechanics measurement at different PEEP
Hemodynamics changes measurement at different PEEP
Eligibility Criteria
You may qualify if:
- COVID-19 patients with mechanical ventilation
- PO2/FIO2\<300mmHg
- ages\>18 years
You may not qualify if:
- pneumothorax
- pregnant
- hemodynamics is unstable
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Zhongda Hospital, Southeast University
Nanjing, Jiangsu, 210009, China
Related Publications (1)
Pan C, Lu C, She X, Ren H, Wei H, Xu L, Huang Y, Xia J, Yu Y, Chen L, Du B, Qiu H. Evaluation of Positive End-Expiratory Pressure Strategies in Patients With Coronavirus Disease 2019-Induced Acute Respiratory Distress Syndrome. Front Med (Lausanne). 2021 Jul 20;8:637747. doi: 10.3389/fmed.2021.637747. eCollection 2021.
PMID: 34355001DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Officials
- STUDY DIRECTOR
Chun C Pan
Zhongda hospital, Southeast University, Jiangsu, China
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- NON RANDOMIZED
- Masking
- NONE
- Purpose
- TREATMENT
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Dr
Study Record Dates
First Submitted
April 13, 2020
First Posted
April 24, 2020
Study Start
March 5, 2020
Primary Completion
March 25, 2020
Study Completion
March 25, 2020
Last Updated
April 24, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share