Damage and Renal Clearance of Glycocalyx in Cardiac Surgery
GlycoCarSur
1 other identifier
observational
21
1 country
1
Brief Summary
The glycocalyx is a component of the vascular endothelium that currently plays a relevant role in the modified Starling theory. The manipulation of the heart during cardiac surgery stimulates the release of the natriuretic atrial peptide, which causes endothelial wear in patients undergoing extracorporeal circulation. Dilation of the atrium produces natriuretic atrial peptide, which reduces plasma volume by increasing renal excretion and vascular permeability. The atrial peptide degrades the surface of the coronary endothelium, causing loss of the side cam protein nucleus. This study investigates the relationship between clamping time in cardiac surgery and the clearance of endothelial inflammation markers.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Aug 2017
Shorter than P25 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
August 1, 2017
CompletedPrimary Completion
Last participant's last visit for primary outcome
October 1, 2017
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2017
CompletedFirst Submitted
Initial submission to the registry
April 1, 2020
CompletedFirst Posted
Study publicly available on registry
April 3, 2020
CompletedApril 9, 2020
April 1, 2020
2 months
April 1, 2020
April 7, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (10)
Extracorporeal circulation time
Duration of Extracorporeal Circulation in minutes
2 hours
Aortic clamping time
Duration of aortic clamping time in minutes
2 hours
Hyaluronic acid levels in blood before surgery
Quantity of hyaluronic acid in blood before surgery
30 minutes
Hyaluronic acid levels in blood after surgery
Quantity of hyaluronic acid in blood after surgery
30 minutes
Hyaluronic acid levels in urine before surgery
Quantity of hyaluronic acid in urine before surgery
30 minutes
Hyaluronic acid levels in urine after surgery
Quantity of hyaluronic acid in urine before surgery
30 minutes
Sydecan -1 levels in blood before surgery
Quantity of Sydecan -1 in blood before surgery
30 minutes
Sydecan -1 levels in blood after surgery
Quantity of Sydecan -1 in blood after surgery
30 minutes
Sydecan -1 levels in urine before surgery
Quantity of Sydecan -1 in urine before surgery
30 minutes
Sydecan -1 levels in urine after surgery
Quantity of Sydecan -1 in urine after surgery
30 minutes
Eligibility Criteria
Patients who meet the selection criteria undergoing cardiac surgery for a single valve change or replacement.
You may qualify if:
- Over 18 years of age
- Patients who underwent cardiac surgery for a single valve change or replacement
You may not qualify if:
- Stage 3 renal failure patients
- Patients with a previous diagnosis of hematological malignancy
- Patients undergoing pulmonary valve change surgery.
- Patients undergoing Bentall and Bono surgery.
- Patients Undergoing Coronary Artery Bypass Surgery
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Hospital Beneficencia Española de Puebla
Puebla City, 72090, Mexico
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- NETWORK
- Responsible Party
- SPONSOR INVESTIGATOR
- PI Title
- cardiovascular critical care unit director
Study Record Dates
First Submitted
April 1, 2020
First Posted
April 3, 2020
Study Start
August 1, 2017
Primary Completion
October 1, 2017
Study Completion
December 31, 2017
Last Updated
April 9, 2020
Record last verified: 2020-04
Data Sharing
- IPD Sharing
- Will not share