Association Between Renal and Right Cardiac Functions After Urinary Sodium Depletion Following Cardiac Surgery

NCT03684876 | Terminated

• 1 other identifier: PI2018_843_0012
• Study Type: observational
• Target: 9
• Locations: 1 country
• Sites: 1

Brief Summary

Following cardiac surgery, right ventricular function may be altered leading to increase central venous pressure and decrease in renal blood flow. The investigator's standard care includes use of diuretic to avoid interstitial fluid accumulation. The aim of the study is to assess cardiac and renal function before and after depletion by using diuretics

Conditions

Cardiorenal Syndrome

Keywords

cardiac surgery; venous congestion; diuretic depletion

Outcome Measures

Primary Outcomes (1)

• change in renal glomerular filtration before and 6 hours after use of diurectic

  change in renal glomerular filtration before and 6 hours after use of diurectic

  at baseline (o hours) and 6 hours after use of diuretic

Interventions

diuretic use PROCEDURE

use of diuretic

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

patient age \>=18 years

You may qualify if:

• patient undergoing elective cardiac surgery under cardiopulmonary bypass

You may not qualify if:

• heart transplantation
• use of vasopressor
• chronic renal disease (DGF under 30 ml min-1)
• endocarditis
• patient under ECLS or CPIA
• patient under 18-year-old

Sponsors & Collaborators

• Centre Hospitalier Universitaire, Amiens: lead

Study Sites (1)

CHU Amiens Picardie

Amiens, France

Location

MeSH Terms

Conditions

Cardio-Renal Syndrome; Hyperemia

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases; Heart Failure; Heart Diseases; Cardiovascular Diseases; Vascular Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: July 5, 2018
• First Posted: September 26, 2018
• Study Start: June 1, 2018
• Primary Completion: June 1, 2020
• Study Completion: June 1, 2020
• Last Updated: June 25, 2026

Record last verified: 2026-06

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)