NCT04327947

Brief Summary

The research was conduct with 3 different products for use in the intimate region in up to 70 research participants, that use the investigational product by 35 ± 2 days. The subjects were follow up throughout the study by a gynecologist for verification of safety, effectiveness and possible adverse events.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
65

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Nov 2019

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

November 6, 2019

Completed
1 month until next milestone

Primary Completion

Last participant's last visit for primary outcome

December 10, 2019

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

February 21, 2020

Completed
1 month until next milestone

First Submitted

Initial submission to the registry

March 26, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

March 31, 2020

Completed
Last Updated

April 3, 2020

Status Verified

April 1, 2020

Enrollment Period

1 month

First QC Date

March 26, 2020

Last Update Submit

April 1, 2020

Conditions

Outcome Measures

Primary Outcomes (1)

  • Perceived hydration

    Evaluate the perceived hydration, through a subjective questionnaire based on "Standard Guide for Sensory Claim Substantiation"

    9 days

Study Arms (3)

women, 18-39 y

EXPERIMENTAL

Health volunteers, 18-39 y, with vaginal dryness

Other: Hyaluronic acid - Research product 1Other: Hyaluronic acid - Research product 2Other: Hyaluronic acid - Comparator product

premenopause women

EXPERIMENTAL

Health volunteers, 40 years to premenopause, with vaginal dryness

Other: Hyaluronic acid - Research product 1Other: Hyaluronic acid - Research product 2Other: Hyaluronic acid - Comparator product

climacteric women

ACTIVE COMPARATOR

Health volunteers, climacteric, with vaginal dryness

Other: Hyaluronic acid - Research product 1Other: Hyaluronic acid - Research product 2Other: Hyaluronic acid - Comparator product

Interventions

Health care product (intimate gel)

climacteric womenpremenopause womenwomen, 18-39 y

Health care product (intimate gel)

climacteric womenpremenopause womenwomen, 18-39 y

Health care product (intimate gel)

climacteric womenpremenopause womenwomen, 18-39 y

Eligibility Criteria

Age18 Years - 70 Years
Sexfemale
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Health volunteers
  • Non-injured mucosa in the test region;
  • Agreement to adhere to study procedures and requirements and attend the institute on the day(s) and time(s) determined for the evaluations;
  • Ability to consent to their participation in the study;
  • Age from 18 to 70 years old;
  • Female participants;
  • Vaginal dryness (slight minimum) - according to questions from the gynecologist.

You may not qualify if:

  • Pregnancy or breastfeeding;
  • Skin pathology in the area of application of the product;
  • Diabetes Mellitus type 1; insulin-dependent diabetes; presence of complications due to diabetes (retinopathy, nephropathy, neuropathy); presence of diabetes-related dermatoses (plantar ulcer, lipoid necrobiosis, annular granuloma, opportunistic infections); history of episodes of hypoglycemia, diabetic ketoacidosis and/or hyperosmolar coma;
  • Current use of the following medications for topical or systemic use:
  • corticosteroids, immunosuppressants and antihistamines;
  • Skin diseases: vitiligo, psoriasis, lupus, atopic dermatitis;
  • History of reaction to the category of the tested product;
  • Other diseases or medications that may directly interfere with the study or endanger the health of the research participant.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Allergisa Pesquisa Dermato-Cosmética Ltda

Campinas, Brazil

Location

MeSH Terms

Conditions

Atrophic VaginitisVaginal Diseases

Condition Hierarchy (Ancestors)

VaginitisGenital Diseases, FemaleFemale Urogenital DiseasesFemale Urogenital Diseases and Pregnancy ComplicationsUrogenital DiseasesGenital Diseases

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
SINGLE
Who Masked
PARTICIPANT
Purpose
TREATMENT
Intervention Model
PARALLEL
Model Details: Clinical trial, triple arm, randomized
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 26, 2020

First Posted

March 31, 2020

Study Start

November 6, 2019

Primary Completion

December 10, 2019

Study Completion

February 21, 2020

Last Updated

April 3, 2020

Record last verified: 2020-04

Locations