Development of a Research Infrastructure for Understanding and Addressing Multiple Myeloma Disparities

NCT04314752 | Recruiting

• 1 other identifier: 1487154
• Study Type: observational
• Target: 4,000
• Locations: 1 country
• Sites: 1

Brief Summary

The objectives of the proposed study are to develop and evaluate protocols for ethnic/racial minority-specific research using cancer registry data. In conjunction with the Cancer Registry of Greater California (CRGC), the investigators have developed procedures to identify, recruit, and survey ethnic/racial minority patients with MM. To pilot the study, the investigators aim initially to test the feasibility of this protocol by contacting 400 eligible patients (100 African Americans, 100 Latinos, 100 Asian American/Native Hawaiian/Pacific Islander-AANHPI and 100 non-Hispanic Whites as a comparison group) to conduct a pilot survey through which will ascertain etiological and survival-related factors for MM. Ultimately, the investigators hope the findings from this pilot will yield insight into the best practices for recruiting minorities with MM and serve as the basis for larger population-based studies of MM etiology and survival. The next phase of this study is to expand the study to all 3 California Cancer Registries, including the Greater Bay Area Cancer Registry and the Los Angeles Cancer Surveillance Program and Cancer Registry of Greater California. We will increase the sample size to recruit atleast 1000 participants per racial/ethnic group. We will also request to increase the scope of the study to also continue a survivorship cohort.

Conditions

Multiple Myeloma

Outcome Measures

Primary Outcomes (2)

• Review the response rate of mailed out surveys, compared by race/ethnicity and disease status

  Response Rate in percentage

  2025

• Response rate for saliva kits compared to survey response and determine if there is a disparity in participation between race/ethnic groups

  Response Rates in percentage

  2025

Eligibility Criteria

• Age: 21 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We will recruit 4,000 participants (1000 Latinos/ 1000 African Americans/ 1000 Asian American/Native Hawaiian/Pacific Islanders/ 1000 Non-Hispanic Whites). Participants will be randomly selected from cancer registry using the criteria above.

You may qualify if:

• Diagnosed with a first primary pathologically confirmed case of Multiple Myeloma within the previous 5 years
• At least 21 years of age at the time of diagnosis
• Must have been diagnosed in one of the 48 counties in California
• Participant must be alive
• Identify as one of the following: African American, Latino, Asian American/Native Hawaiian/Pacific Islander, Non-Hispanic White

You may not qualify if:

• People who have not been diagnosed with Multiple Myeloma
• Under the age of 21
• Pregnant
• Prisoner

Sponsors & Collaborators

• University of California, Davis: lead
• Cancer Registry of Greater California: collaborator

Study Sites (1)

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Study team will collect 2ml of saliva from participants who consent to the biospecimen collection portion of the study. Saliva will be used for genetic and genomic research

MeSH Terms

Conditions

Multiple Myeloma

Condition Hierarchy (Ancestors)

Neoplasms, Plasma Cell; Neoplasms by Histologic Type; Neoplasms; Hemostatic Disorders; Vascular Diseases; Cardiovascular Diseases; Paraproteinemias; Blood Protein Disorders; Hematologic Diseases; Hemic and Lymphatic Diseases; Hemorrhagic Disorders; Lymphoproliferative Disorders; Immunoproliferative Disorders; Immune System Diseases

Study Officials

• Luis Carvajal-Carmona, PhD

  University of California, Davis

  PRINCIPAL INVESTIGATOR

• Rosemary Cress, DrPh MPH

  Cancer Registry of California

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Luis Carvajal-Carmona, PhD

CONTACT

5307529654; lgcarvajal@ucdavis.edu

Angelica Perez, BS

CONTACT

9167344563; amiperez@ucdavis.edu

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: OTHER
• Target Duration: 5 Years
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 9, 2020
• First Posted: March 19, 2020
• Study Start: September 1, 2020
• Primary Completion (Estimated): May 30, 2026
• Study Completion (Estimated): May 30, 2026
• Last Updated: September 25, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)