Effects of Rehydration During Physical Exercise on Acute Kidney Injury Biomarkers
1 other identifier
interventional
30
1 country
1
Brief Summary
Rehydration during and after physical exercise is essential to avoid acute kidney injury. Soft drinks are commonly used during exercise. High intake of carbohydrates is leading to obesity and metabolic disorders. Fructose intake is leading to uric acid abnormalities and kidney injury. 30 healthy soccer players will be studied. During four training sessions subjects will intake 500 ml 7% soft drinks containing glucose, fructose, saccharose or xylitol. Changes in acute kidney injury markers, markers of kidney tubular function as well as changes in CRP, glucose, cholesterol and uric acid levels will be studied..
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started Mar 2020
Shorter than P25 for not_applicable
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
March 9, 2020
CompletedStudy Start
First participant enrolled
March 9, 2020
CompletedFirst Posted
Study publicly available on registry
March 17, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
September 1, 2020
CompletedStudy Completion
Last participant's last visit for all outcomes
December 31, 2020
CompletedMarch 17, 2020
March 1, 2020
6 months
March 9, 2020
March 16, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (2)
Change in urinary AKI biomarkers (urianry NGAL, urinary KIM -1, urinary cystatin-C) after physical exercise
after 60-90 min of pysical exercise
Changes in fractional uric acid excretion
after 60-90 min of pysical exercise
Study Arms (4)
Experimental: glucose - fructose - xylitol - saccharose
ACTIVE COMPARATOR* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: fructose - glucose - saccharose - xylitol
ACTIVE COMPARATOR* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: xylitol - saccharose - glucose - fructose
ACTIVE COMPARATOR* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Experimental: saccharose - xylitol - fructose - glucose
ACTIVE COMPARATOR* glucose 35 g (500ml of 7% solution); * fructose 35 g (500ml of 7% solution); * xylitol 35 g (500ml of 7% solution); * saccharose 35 g (500ml of 7% solution)
Interventions
1. Intervention: rehydration with glucose solution. Glucose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 2. Intervention: rehydration with fructose solution. Fructose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 3. Intervention: rehydration with xylitol solution. Xylitol will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m. 4. Intervention: rehydration with sucrose solution Saccharose will be administered at a dose of 35 mg (500 ml of 7% solution) taken orally once, in the middle of soccer training session, at approximately 10.00 a.m.
Eligibility Criteria
You may qualify if:
- age above 18 years
- well-trained soccer players
- informed consent
You may not qualify if:
- chronic diseases, especially kidney problems
- sigificant changes in urinalysis
- creatinine level above normal values
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Medical University of Gdansk
Gdansk, Poland
Related Publications (1)
Wolyniec W, Szwarc A, Kasprowicz K, Zorena K, Jaskulak M, Renke M, Naczyk M, Ratkowski W. Impact of hydration with beverages containing free sugars or xylitol on metabolic and acute kidney injury markers after physical exercise. Front Physiol. 2022 Oct 20;13:841056. doi: 10.3389/fphys.2022.841056. eCollection 2022.
PMID: 36338481DERIVED
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Officials
- STUDY CHAIR
Marcin Renke, prof
Medical University of Gdansk
Central Study Contacts
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- INVESTIGATOR
- Purpose
- DIAGNOSTIC
- Intervention Model
- CROSSOVER
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Principal Investigator
Study Record Dates
First Submitted
March 9, 2020
First Posted
March 17, 2020
Study Start
March 9, 2020
Primary Completion
September 1, 2020
Study Completion
December 31, 2020
Last Updated
March 17, 2020
Record last verified: 2020-03