Texture Features and PDL1 in CT-PET 18 FDG

NCT04309422 | Completed

• 1 other identifier: RECHMPL19_0623
• Study Type: observational
• Target: 84
• Locations: 1 country
• Sites: 1

Brief Summary

Search correlation between texture features in CT-PET 18 FDG and overexpression of PDL1 in non-small cell lung carcinomas during the inital staging. The hypothesis is that overexpression of PDL1is correlated with at least one texture feature among those selected. 84 CT-PET 18 FDG at the initial staging of a non small cell lung carcinoma (adenocarcinoma or squamous cell carcinoma), whose the biopsed site was the primitive site or the drainage lymphadenopathy, without previous treatment, were recruited and analyzed by a software allowing to estimate texture features.

Conditions

Non Small Cell Lung Cancer

Keywords

Correlation between overexpression of PDL1; texture features; CT-PET 18 FDG; Non Small Cell Lung Carcinoma

Outcome Measures

Primary Outcomes (1)

• Correlation between at least one texture feature and overexpression of PDL1

  Correlation between at least one texture feature and overexpression of PDL1

  1 day

Study Arms (2)

Overexpression of PDL1

Overexpression of PDL1

Absence of overexpression of PDL1

Absence of overexpression of PDL1

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patient with initial CT-PET 18 FDG realized in the nuclear service of Montpellier university hospital, with non small cell lung carcinoma diagnosed with biopsy of the primitive site or local drainage lymphadenopathy.

You may qualify if:

• adult patient ;
• first CT-PET 18 FDG realized for the inital staging ;
• absence of previous treatment for a thoracic neoplasm ;
• biopsy realized on the primitive site or local drainage lymphadenopathy ;
• primitive site viewable with morphological imagery ;
• availability of evaluation of PDL1's overexpression ;

You may not qualify if:

• \- Refusal to participate in this research

Sponsors & Collaborators

• University Hospital, Montpellier: lead

Study Sites (1)

Uh Montpellier

Montpellier, 34295, France

Location

MeSH Terms

Conditions

Carcinoma, Non-Small-Cell Lung

Condition Hierarchy (Ancestors)

Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms by Site; Neoplasms; Lung Diseases; Respiratory Tract Diseases

Study Officials

• Jean-Baptiste MALLET

  University Hospitals of Montpellier

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 12, 2020
• First Posted: March 16, 2020
• Study Start: April 1, 2018
• Primary Completion: October 1, 2018
• Study Completion: January 31, 2020
• Last Updated: March 18, 2020

Record last verified: 2020-03

Locations

FR (1)