NCT04307719

Brief Summary

The Jewish Population is at an increased risk for genetic diseases, especially autosomal recessive, thus, screening should be done to determine carrier status of several genetic diseases. In the Mexican Jewish Community, which is a very diverse community (regarding geographical origins), data of carrier status is unknown. The study aims to determine carrier prevalence for over 300 diseases using commercially available panels.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
208

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jul 2020

Shorter than P25 for all trials

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 11, 2020

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 13, 2020

Completed
4 months until next milestone

Study Start

First participant enrolled

July 1, 2020

Completed
9 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

April 10, 2021

Completed
9 days until next milestone

Study Completion

Last participant's last visit for all outcomes

April 19, 2021

Completed
Last Updated

April 21, 2021

Status Verified

April 1, 2021

Enrollment Period

9 months

First QC Date

March 11, 2020

Last Update Submit

April 20, 2021

Conditions

Genetic PredispositionCarrier, Gestational

Keywords

Carrier ScreeningJewish

Outcome Measures

Primary Outcomes (1)

  • Carrier Status for 300+ Genetic Diseases

    Patients will be screened for over 300 genetic diseases to determine carrier status

    30 days after sample collection

Study Arms (1)

Mexican Jewish Community

Sample of Patients from the Mexican Jewish Community to be subjected to genetic testing

Eligibility Criteria

Age18 Years - 35 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)
Sampling MethodNon-Probability Sample
Study Population

Representative sample of the Mexican Jewish Community of child-bearing age, of both sexes.

You may qualify if:

  • Jewish Origin in at least 1 grandparent
  • Members of one of the Jewish sub-Communities in Mexico City

You may not qualify if:

  • Pregnant Women

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Universidad Anáhuac México

Huixquilucan, State of Mexico, 52786, Mexico

Location

Biospecimen

Retention: SAMPLES WITH DNA

Saliva samples for commercially available DNA carrier screening panels

MeSH Terms

Conditions

Genetic Predisposition to Disease

Condition Hierarchy (Ancestors)

Disease SusceptibilityDisease AttributesPathologic ProcessesPathological Conditions, Signs and Symptoms

Study Officials

  • Dan Morgenstern-Kaplan, MD

    Anahuac University

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
observational
Observational Model
ECOLOGIC OR COMMUNITY
Time Perspective
CROSS SECTIONAL
Target Duration
1 Day
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Principal Investigator

Study Record Dates

First Submitted

March 11, 2020

First Posted

March 13, 2020

Study Start

July 1, 2020

Primary Completion

April 10, 2021

Study Completion

April 19, 2021

Last Updated

April 21, 2021

Record last verified: 2021-04

Data Sharing

IPD Sharing
Will not share

Locations

ME(1)