Dynamic Neural Mechanisms of Audiovisual Speech Perception

NCT04290130 | Enrolling By Invitation

• 1 other identifier: 844668
• Study Type: interventional
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.

Conditions

Speech Perception

Outcome Measures

Primary Outcomes (1)

• Measurement of neural activity

  The name of the measurement is the broadband high-frequency activity (BHA) in the brain in response to audiovisual speech. The unit of measure is % increase in power from pre-stimulus baseline. The name of the measurement tool is intracranial EEG, recordings of the raw voltage signal from each electrode implanted in the brain. The voltage-by-time signal will be converted to spectral space using a wavelet transform, and the magnitude of the power between 70 and 150 Hz inclusive in a time window between 0 ms and 500 ms after stimulus onset will be calculated.

  During the procedure.

Interventions

Measurement of brain activity using electrodes. OTHER

We will present audiovisual speech and record neural responses.

Eligibility Criteria

• Age: 21 Years - 65 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• must be undergoing neurosurgery for the treatment of a brain disorder

You may not qualify if:

• must have corrected-to-normal vision and hearing

Sponsors & Collaborators

• University of Pennsylvania: lead
• Columbia University: collaborator
• Baylor College of Medicine: collaborator

Study Sites (1)

University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Location

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 25, 2020
• First Posted: February 28, 2020
• Study Start: September 15, 2019
• Primary Completion (Estimated): May 31, 2026
• Study Completion (Estimated): May 31, 2026
• Last Updated: September 10, 2025

Record last verified: 2025-09

Data Sharing

• IPD Sharing: Will not share

Locations

US (1)