Effect of Blood Flow Restriction Training on Patient With Anterior Cruciate Ligament Reconstruction

NCT04284748 | Completed DMC

• 1 other identifier: KA-180096
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates the effects of plyometric training with blood flow restriction on muscular strength, quadriceps thickness and knee joint function in patients with muscle weakness and atrophy (quadriceps muscle and hamstring muscle) after anterior cruciate ligament reconstruction. Persons who completed a 12-week routine rehabilitation program after anterior cruciate ligament reconstruction will be included in the study. In the study group, plyometric exercises will be performed with blood flow restriction in the operated side for 8 weeks. In the control group, the same plyometric exercises will be performed without any application.

Conditions

Anterior Cruciate Ligament Injuries; Atrophy; Muscle Weakness

Keywords

anterior cruciate ligament reconstruction; atrophy; knee function

Outcome Measures

Primary Outcomes (2)

• Quadriceps muscle thickness and rectus femoris cross-sectional ares

  Thickness of rectus femoris, vastus medialis obliques, vastus lateralis muscles and cross-sectional area of rectus femoris were measured using a B-mode ultrasound device with a 9L4 linear probe before and after plyometric training.

  8 week

• Hamstring and quadriceps muscle strength

  Quadriceps and hamstring muscle strength (isometric, concentric and eccentric) were evaluated with an isokinetic dynamometer (IsoMed2000 D\&R GmbH, Germany) before and plyometric training.

  8 week

Secondary Outcomes (8)

• Vertical jump test (VJT)

  8 week

• One leg hop test (OLHT)

  8 week

• Single leg triple hop test (SLTHT)

  8 week

• Y balance test

  8 week

• Knee Documentation Committee (IKDC) Questionnaire

  8 week

Study Arms (2)

Plyometric training with blood flow restriction

EXPERIMENTAL

Routine physiotherapy program + Plyometric training with blood flow restriction, 3 days a week for 8 weeks Jump in functional squat system (30+15+15+15= 75 rep) Lunge jump (30 rep) Side jump (30 rep) Box jump (15 rep) Exercises to be added after 4 weeks; Square jump (15 rep) One leg hop (15 rep)

Other: Plyometric exercise with blood flow restriction; Other: Routine physiotherapy program

Plyometric training

ACTIVE COMPARATOR

Routine physiotherapy program + Plyometric training 3 days a week for 8 weeks Jump in functional squat system (30+15+15+15= 75 rep) Lunge jump (30 rep) Side jump (30 rep) Box jump (15 rep) Exercises to be added after 4 weeks; Square jump (15 rep) One leg hop (15 rep)

Other: Plyometric exercise; Other: Routine physiotherapy program

Interventions

Plyometric exercise with blood flow restriction OTHER

Blood flow restriction training is an exercise protocol based on the method of limiting blood flow with external pressure by pneumatic tourniquet from the proximal of the muscle to be strengthened. Blood flow restriction (Occlusion) during pliometric exercises for 8 weeks, a pneumatic tourniquet (Kaatsu Master) proximal to the thigh will be applied to each patient within a safe pressure range. The pressure to be applied to the patient will be calculated with the following formula described in the literature. Pressure = 0.5 x (systolic blood pressure) + 2 x (thigh circumference) + 5 Application will be done for a maximum of 15 minutes, then rest for 10-15 minutes and other exercises will continue. Plyometric training with blood flow restriction. Jump in functional squat system (30+15+15+15= 75 rep) Lunge jump (30 rep) Side jump (30 rep) Box jump (15 rep) Exercises to be added after 4 weeks; Square jump (15 rep) One leg hop (15 rep)

Plyometric training with blood flow restriction

Plyometric exercise OTHER

Plyometric training Jump in functional squat system (30+15+15+15= 75 rep) Lunge jump (30 rep) Side jump (30 rep) Box jump (15 rep) Exercises to be added after 4 weeks; Square jump (15 rep) One leg hop (15 rep)

Plyometric training

Routine physiotherapy program OTHER

Anterior and lateral plan exercise (3x10 rep) Open kinetic quadriceps and hamstring strengthening exercise (3x10 rep) Lunge exercises on different ground (3x10 rep) Single leg squat exercise on different ground (3x10 rep) Anterior and lateral walking exercise in a squatting position with an exercise band (40 step) Balance and proprioceptive exercises

Plyometric training; Plyometric training with blood flow restriction

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• Age between 18-45 year
• Volunteering to participate in the study
• Patients who had unilateral anterior cruciate ligament surgery with hamstring tendon auto graft and completed 12 weeks of rehabilitation program

You may not qualify if:

• Systemic or neurological problems
• Endothelial dysfunction
• Peripheral vascular diseases and history of deep vein thrombosis
• Active infection, cancer, pregnant,
• Posterior cruciate ligament tear, medial or lateral collateral ligament tear and knee cartilage damage

Sponsors & Collaborators

• Hacettepe University: lead

Study Sites (1)

Hacettepe University, Department of Physical Therapy and Rehabilitation

Ankara, 06100, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Anterior Cruciate Ligament Injuries; Atrophy; Muscle Weakness

Interventions

Plyometric Exercise

Condition Hierarchy (Ancestors)

Knee Injuries; Leg Injuries; Wounds and Injuries; Pathological Conditions, Anatomical; Pathological Conditions, Signs and Symptoms; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Pathologic Processes; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Exercise Therapy; Rehabilitation; Aftercare; Continuity of Patient Care; Patient Care; Therapeutics; Physical Therapy Modalities; Physical Conditioning, Human; Exercise; Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Egemen Turhan, MD

  Hacettepe University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: INVESTIGATOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Research Assistant

Study Record Dates

• First Submitted: January 7, 2020
• First Posted: February 26, 2020
• Study Start: December 10, 2018
• Primary Completion: April 15, 2020
• Study Completion: June 15, 2020
• Last Updated: August 11, 2020

Record last verified: 2018-11

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)