Relationship Between Muscle Strength and Physical Function in ICU

NCT04284475 | Completed

• 1 other identifier: MSF
• Study Type: observational
• Target: 93
• Locations: 1 country
• Sites: 1

Brief Summary

This observational study aims to assess the relationship between muscle strength and physical function in critical ill patients. Grip and quadriceps strengths are measured using a standardized protocol of dynamometry. Physical function is assessed using the validated ICU mobility scale.

Conditions

Critical Illness; Muscle Weakness; Physical Disability; Physical Dependence

Outcome Measures

Primary Outcomes (3)

• Quadriceps strength

  Quadriceps maximal isometric strength measured using dynamometry

  as soon as collaborative during ICU stay and up to 1 month following ICU discharge

• Handgrip strength

  Grip maximal isometric strength measured using dynamometry

  as soon as collaborative during ICU stay and up to 1 month following ICU discharge

• ICU mobility scale

  Ranking the patient on the scale according to his/her physical capacity. ICU mobility scale is a 10 points scale: 0 means the patient is lying in bed, 10 means the patient is able to walk independently

  as soon as collaborative during ICU stay and up to 1 month following ICU discharge

Interventions

Quadriceps strength DIAGNOSTIC_TEST

Using a handheld dynamometer, in supine position in a standardized position of the dominant leg Measurement of the maximal isometric voluntary quadriceps contraction Measure expressed as Newton and Newton/kg

Grip strength DIAGNOSTIC_TEST

Testing of dominant hand using a handgrip Measurement of the maximal isometric voluntary grip contraction Measure is expressed as kg

ICU mobility scale DIAGNOSTIC_TEST

Scoring the physical capacity of the patient on a 10-points validated scale: the ICU mobility scale

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study includes all critical ill patients staying in ICU for at least 48 hours. They are screened as soon as they are collaborative.

You may qualify if:

• ICU stay of at least 48h
• Collaborative (RASS score -1 to +1)

You may not qualify if:

• Refusal
• Coma
• Non collaborative
• Hemi / tetra paresis or plegia

Sponsors & Collaborators

• University of Liege: lead

Study Sites (1)

University Hospital of Liège

Liège, 4000, Belgium

Location

MeSH Terms

Conditions

Critical Illness; Muscle Weakness

Interventions

Hand Strength

Condition Hierarchy (Ancestors)

Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Muscular Diseases; Musculoskeletal Diseases; Neuromuscular Manifestations; Neurologic Manifestations; Nervous System Diseases; Signs and Symptoms

Intervention Hierarchy (Ancestors)

Muscle Strength; Physical Examination; Diagnostic Techniques and Procedures; Diagnosis; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Anne-Françoise Rousseau, MD, PhD

  University hospital of Liège

  PRINCIPAL INVESTIGATOR

• Isabelle Kellens, PT, PhD

  University hospital of Liège

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Head of Clinic, Intensive Care Dpt

Study Record Dates

• First Submitted: February 18, 2020
• First Posted: February 25, 2020
• Study Start: October 1, 2018
• Primary Completion: December 31, 2019
• Study Completion: November 1, 2021
• Last Updated: November 26, 2021

Record last verified: 2021-11

Locations

BE (1)