Use of Platelet-rich Plasma in Second-degree Superficial Burns

NCT04276818 | Completed

• 1 other identifier: SBU Konya EAH
• Study Type: interventional
• Target: 62
• Locations: 1 country
• Sites: 1

Brief Summary

Platelet-rich plasma (PRP) obtained from the patient's blood has been used in many clinical and experimental studies, primarily wound healing, and successful results have been achieved. PRP has been used in various studies in the treatment of burn wounds, and positive results have been obtained. However, investigators did not find any study or publication about the use of PRP in second-degree superficial burns in our screening. Investigators planned a prospective randomized controlled and multicenter study to investigate the positive effects of PRP in the treatment of second-degree superficial burn.

Conditions

Burns Degree Second

Keywords

PRP; Burn

Outcome Measures

Primary Outcomes (1)

• PRP use in second degree burn treatment

  In the study, the effectiveness of burn treatment in both groups will be determined by recording the day of epithelialization.

  01.03.2020-30.04.2020

Study Arms (2)

PRP group

ACTIVE COMPARATOR

Second-degree superficial burn group treated with PRP

Procedure: PRP group

conventional treatment group

ACTIVE COMPARATOR

second-degree superficial burn group treated with cream containing silver sulfadiazine

Procedure: conventional treatment group

Interventions

PRP group PROCEDURE

Demonstrating the effectiveness of dressing with PRP in the treatment of second-degree burns

PRP group

conventional treatment group PROCEDURE

The effectiveness of conventional dressing containing silver sulfadiazine in the treatment of burns will be compared with the method of dressing with PRP.

conventional treatment group

Eligibility Criteria

• Age: 16 Years - 90 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)

You may qualify if:

• having a second-degree superficial burn
• To be over the age of 16.

You may not qualify if:

• Patients under 16
• Patients with a burn of more than 30% of the total body surface area.
• Patients with additional trauma with a burn wound.
• Diabetes mellitus, renal failure requiring dialysis and having decompensated heart disease
• Being pregnant and breastfeeding.
• The patient does not want to participate in the study.

Sponsors & Collaborators

• Konya Meram State Hospital: lead

Study Sites (1)

Konya Training and Research Hospital

Konya, 42090, Turkey (Türkiye)

Location

Related Publications (3)

• Venter NG, Marques RG, Santos JS, Monte-Alto-Costa A. Use of platelet-rich plasma in deep second- and third-degree burns. Burns. 2016 Jun;42(4):807-14. doi: 10.1016/j.burns.2016.01.002. Epub 2016 Jan 25.

  PMID: 26822695 BACKGROUND

• Grippaudo FR, Carini L, Baldini R. Procutase versus 1% silver sulphadiazine in the treatment of minor burns. Burns. 2010 Sep;36(6):871-5. doi: 10.1016/j.burns.2009.10.021. Epub 2010 Jan 15.

  PMID: 20079572 BACKGROUND

• Zheng W, Zhao DL, Zhao YQ, Li ZY. Effectiveness of platelet rich plasma in burn wound healing: a systematic review and meta-analysis. J Dermatolog Treat. 2022 Feb;33(1):131-137. doi: 10.1080/09546634.2020.1729949. Epub 2020 Feb 21.

  PMID: 32048887 BACKGROUND

MeSH Terms

Conditions

Burns

Condition Hierarchy (Ancestors)

Wounds and Injuries

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: February 17, 2020
• First Posted: February 19, 2020
• Study Start: March 1, 2020
• Primary Completion: September 30, 2020
• Study Completion: October 23, 2020
• Last Updated: November 2, 2020

Record last verified: 2020-10

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)