Vinorelbine, Cisplatin, Disulfiram and Copper in CTC_EMT Positive Refractory Metastatic Breast Cancer.

NCT04265274 | Withdrawn Phase 2

• 1 other identifier: BREAST-SK-001
• Study Type: interventional
• Target: N/A
• Locations: 1 country
• Sites: 1

Brief Summary

This is a proof-of-concept study to define efficacy of vinorelbine, cisplatin, disulfiram and copper in CTC\_EMT positive refractory metastatic hormone receptor positive, HER2 negative breast cancer.

Conditions

Metastatic Breast Cancer

Keywords

metastatic breast cancer, vinorelbin, cisplatin, disulfiram

Outcome Measures

Primary Outcomes (1)

• Objective response rates

  Response rate according to RECIST

  6 months

Secondary Outcomes (2)

• Progression-free survival

  12 months

• overall survival

  12 months

Study Arms (1)

Disulfiram, vinorelbin, cisplatin, copper

EXPERIMENTAL

Vinorelbine 25mg/m2 day 1 and 8, Cisplatin 75mg/m2 day 1, every 3 weeks, Disulifiram um 400mg daily and 2 mg of elementary Copper daily, continuously.

Drug: Disulfiram; Drug: Vinorelbin; Drug: Cisplatin; Drug: Copper

Interventions

Disulfiram DRUG

dosing 400mg daily

Also known as: Antabus

Disulfiram, vinorelbin, cisplatin, copper

Vinorelbin DRUG

25mg/m2 day 1 and 8,

Also known as: Navelbine

Disulfiram, vinorelbin, cisplatin, copper

Cisplatin DRUG

75mg/m2 day 1

Disulfiram, vinorelbin, cisplatin, copper

Copper DRUG

2 mg of elementary Copper daily

Disulfiram, vinorelbin, cisplatin, copper

Eligibility Criteria

• Age: 18 Years+
• Gender Eligibility Details: female breast cancer
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• \) CTC\_EMT positivity in the peripheral blood. 3) Patients with locally recurrent or metastatic disease hormone receptor positive, HER2 negative, who have received at least two (and not more than five) prior chemotherapeutic regimens for breast cancer, at least two of which were administered for treatment of locally recurrent and/or metastatic disease.
• \) Prior therapy must be documented by the following criteria prior to entry onto study:
• Regimens must have included an anthracycline (e.g., doxorubicin, epirubicin) and a taxane (e.g., paclitaxel, docetaxel) in any combination or order. Treatment with any of these agents is not required if they are contraindicated for a certain patient.
• One or two of these regimens may have been administered as adjuvant and/or neoadjuvant therapy, but at least 2 must have been given for relapsed or metastatic disease.
• Patients must have proved refractory to the most recent chemotherapy, documented by progression on or within six (6) months of therapy.
• \) Patients may have additionally been treated with anti-hormonal therapy. 6) Resolution of all chemotherapy or radiation-related toxicities to Grade 1 severity or lower, except for stable sensory neuropathy \<= Grade 2 and alopecia.
• \) Age \>= 18 years. 8) Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 to 2. 9) Life expectancy of \>= 3 months. 10) Adequate renal function as evidenced by calculated creatinine clearance \>= 40 mL/min per the Cockcroft and Gault formula.
• \) Adequate bone marrow function as evidenced by absolute neutrophil count (ANC) \>= 1.5 x 10\^9/L, hemoglobin \>= 9.0 g/dL (a hemoglobin \<10.0 g/dL is acceptable if it is corrected by growth factor or transfusion), and platelet count \>= 100 x 10\^9/L.
• \) Adequate liver function as evidenced by bilirubin \<= 1.5 times the upper limits of normal (ULN) and alkaline phosphatase, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) \<= 3 x ULN (in the case of liver metastases \<= 5 x ULN), unless there are bone metastases, in which case liver specific alkaline phosphatase must be separated from the total and used to assess the liver function instead of the total alkaline phosphatase. In case alkaline phosphatase is \>3 x ULN (in absence of liver metastases) or \> 5 x ULN (in presence of liver metastases) AND patient is known to have bone metastases, the liver specific alkaline phosphatase must be separated from the total and used to assess the liver function instead of the total alkaline phosphatase.
• \) Patients willing and able to comply with the study protocol for the duration of the study.
• \) Written informed consent prior to any study-specific screening procedures with theunderstanding that the patient may withdraw consent at any time without prejudice.

You may not qualify if:

• Patients who have received any of the following treatments within the specified period before study treatment start: chemotherapy, radiation, trastuzumab or hormonal therapy within three weeks, any investigational drug within four weeks, radiation therapy encompassing \> 30% of marrow.
• Addiction to alcohol or drugs.
• Need for metronidazole, warfarin and/or theophylline medication, the metabolism of which is likely influenced by disulfiram and copper, see Table 4.
• Patients who are taking medications metabolized by cytochrome P450 2E1, including chlorzoxazone or halothane and its derivatives, see Table 4.
• Pulmonary lymphangitic involvement that results in pulmonary dysfunction requiring active treatment, including the use of oxygen.
• Patients with brain or subdural metastases are not eligible, unless they have completed local therapy and have discontinued the use of corticosteroids for this indication for at least 4 weeks before starting treatment in this study. Any signs (e.g., radiologic) and/or symptoms of brain metastases must be stable for at least 4 weeks before starting study treatment; radiographic stability should be determined by comparing a contrast-enhanced computed tomography or magnetic resonance imaging brain scan performed during screening to a prior scan performed at least 4 weeks earlier.
• Patients with meningeal carcinomatosis.
• Women who are pregnant or breast-feeding; women of childbearing potential with either a positive pregnancy test at screening or no pregnancy test; women of childbearing potential unless (1) surgically sterile or (2) using adequate measures of contraception in the opinion of the Investigator. Perimenopausal women must be amenorrheic for at least 12 months to be considered of non-childbearing potential.
• Severe/uncontrolled intercurrent illness/infection.
• Patients with organ allografts requiring immunosuppression.
• Patients with known positive HIV status.
• Hemochromatosis.
• Patients who have had a prior malignancy, other than previous breast cancer, carcinoma in situ of the cervix, or non-melanoma skin cancer, unless the prior malignancy was diagnosed and definitively treated \>= 5 years previously with no subsequent evidence of recurrence.
• Patients with pre-existing neuropathy \> Grade 2.
• Patients with other significant disease or disorders that, in the Investigator's opinion, would exclude the patient from the study.

Sponsors & Collaborators

• National Cancer Institute, Slovakia: lead

Study Sites (1)

National Cancer Institute

Bratislava, 83310, Slovakia

Location

MeSH Terms

Conditions

Breast Neoplasms

Interventions

Disulfiram; Vinorelbine; Cisplatin; Copper

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Breast Diseases; Skin Diseases; Skin and Connective Tissue Diseases

Intervention Hierarchy (Ancestors)

Ditiocarb; Thiocarbamates; Carbamates; Acids, Acyclic; Carboxylic Acids; Organic Chemicals; Disulfides; Sulfides; Sulfur Compounds; Vinca Alkaloids; Secologanin Tryptamine Alkaloids; Indole Alkaloids; Alkaloids; Heterocyclic Compounds; Indoles; Heterocyclic Compounds, 2-Ring; Heterocyclic Compounds, Fused-Ring; Indolizidines; Indolizines; Chlorine Compounds; Inorganic Chemicals; Nitrogen Compounds; Platinum Compounds; Metals, Heavy; Elements; Transition Elements; Metals

Study Officials

• Michal Mego, Prof

  National Cancer Institute, Slovakia

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: NA
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: February 5, 2020
• First Posted: February 11, 2020
• Study Start: January 1, 2020
• Primary Completion: January 1, 2022
• Study Completion: January 1, 2023
• Last Updated: October 6, 2023

Record last verified: 2023-10

Data Sharing

• IPD Sharing: Will not share

Locations

SL (1)