NCT04263935

Brief Summary

Correlation Between Driver Gene Abnormalities and Clinicopathological Characteristics and Disease Prognosis in Lymphoma

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
200

participants targeted

Target at P75+ for all trials

Timeline
Completed

Started Jan 2019

Longer than P75 for all trials

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

January 3, 2019

Completed
1.1 years until next milestone

First Submitted

Initial submission to the registry

February 3, 2020

Completed
8 days until next milestone

First Posted

Study publicly available on registry

February 11, 2020

Completed
5.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 30, 2025

Completed
6 months until next milestone

Study Completion

Last participant's last visit for all outcomes

December 31, 2025

Completed
Last Updated

April 23, 2025

Status Verified

April 1, 2025

Enrollment Period

6.5 years

First QC Date

February 3, 2020

Last Update Submit

April 18, 2025

Conditions

Keywords

LymphomaDriver Gene AbnormalitiesDisease Prognosis

Outcome Measures

Primary Outcomes (1)

  • Incidence of driver gene abnormalities

    the incidence of driver gene abnormalities by fixed gene testing technology

    from the day of the first patient was included to the date of the end of this trial, assessed up to 36 months

Secondary Outcomes (3)

  • objective response rate

    from the date of the first patient was included to the date of the end of this trial, assessed up to 36 months

  • 5-year overall survival

    from the date of the first patient was included to the date of the end of this trial, assessed up to 5 years

  • Clinicopathological Characteristics

    from the date of the first patient was included to the date of the end of this trial, assessed up to 36 months

Eligibility Criteria

Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

Including demographic characteristics / clinical characteristics / pathological characteristics / treatment and efficacy evaluations.

You may qualify if:

  • Diagnosed as lymphoma (according to WHO 2017 classification criteria)
  • Life expectancy no less than 3 months
  • Agreeing to sign the written informed consents

You may not qualify if:

  • Other malignant tumor history or active malignant tumor need be treated
  • Researchers determine unsuited to participate in this trial

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Henan Cancer Hospital/The affiliated Cancer Hospital of ZhengZhou university

Zhengzhou, Henan, China

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

Tumor tissue specimen

MeSH Terms

Conditions

Lymphoma

Condition Hierarchy (Ancestors)

Neoplasms by Histologic TypeNeoplasmsLymphoproliferative DisordersLymphatic DiseasesHemic and Lymphatic DiseasesImmunoproliferative DisordersImmune System Diseases

Study Officials

  • Yanyan Liu, M.D. Ph.D

    Henan Cancer Hospital

    STUDY DIRECTOR

Central Study Contacts

Yanyan Liu, M.D. Ph.D

CONTACT

Study Design

Study Type
observational
Observational Model
CASE ONLY
Time Perspective
PROSPECTIVE
Sponsor Type
OTHER GOV
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Director

Study Record Dates

First Submitted

February 3, 2020

First Posted

February 11, 2020

Study Start

January 3, 2019

Primary Completion

June 30, 2025

Study Completion

December 31, 2025

Last Updated

April 23, 2025

Record last verified: 2025-04

Data Sharing

IPD Sharing
Will not share

Locations