CGF and PRF in the Gingival Recessions Treatment
Comparison of Clinical Effects of Concentrated Growth Factor and Platelet-Rich Fibrin in the Treatment of Adjacent Multiple Gingival Recessions: A Split-Mouth Randomized Clinical Trial
1 other identifier
interventional
18
0 countries
N/A
Brief Summary
This study hypothesized that CGFs' placement together with CAF may enhance the healing of soft tissues better than use of PRF together with CAF. Therefore, the aim of this study was to determine the clinical effects of CGF in combination with CAF compared to the clinical effect of PRF in combination with CAF in the treatment of adjacent multiple GRs.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for not_applicable
Started May 2015
Typical duration for not_applicable
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
May 1, 2015
CompletedPrimary Completion
Last participant's last visit for primary outcome
June 1, 2016
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2017
CompletedFirst Submitted
Initial submission to the registry
February 6, 2020
CompletedFirst Posted
Study publicly available on registry
February 10, 2020
CompletedFebruary 10, 2020
February 1, 2020
1.1 years
February 6, 2020
February 6, 2020
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
Complete root coverage
Change from baseline in percentage of complete root coverage at 6th months.
6 months
Secondary Outcomes (4)
Percentage root coverage
6 months
Keratinized gingiva width
6 months
Recession depth
6 th months
Probing depth
6 th months
Study Arms (2)
Concentrated growth Factor Membrane
EXPERIMENTALAutogenous platelet and leukocyte fibrin material was obtained from blood.
Platelet Rich Fibrin
ACTIVE COMPARATORAutogenous platelet and leukocyte fibrin material was obtained from blood.
Interventions
Concentrated growth factor is produced by the centrifugation of venous blood and platelets are concentrated in a gel layer containing fibrin matrix
Platelet Rich Fibrinis produced by the centrifugation of venous blood and platelets are concentrated in a gel layer containing fibrin matrix
Eligibility Criteria
You may qualify if:
- systemically and periodontally healthy,
- non-smokers
- presence of ≥ 2 buccal adjacent Miller Class I and II gingival recession with ≥ 2 mm gingival recession depth , probing depth \<3 mm and gingival thickness (GT) ≥ 1 mm on both sides of the maxillary arch
- width of keratinized gingiva ≥ 2mm
- presence of identifiable cemento-enamel junction
- full-mouth plaque index (PI) \< 20 % and gingival index (GI) scores \<1,
- presence of tooth vitality and absence of caries, restorations and furcation involvement in the treated area,
You may not qualify if:
- patients who had systemic problems that wound contraindicate for periodontal surgery, - usage of medications known to interfere with healing and to cause gingival enlargement - recession defects associated with demineralization, deep abrasion,
- previous surgery in the defects area within the past 1 year,
- pregnant or lactating females
- drug and alcohol abuse
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- SINGLE
- Who Masked
- OUTCOMES ASSESSOR
- Purpose
- TREATMENT
- Intervention Model
- SINGLE GROUP
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Associate Professor
Study Record Dates
First Submitted
February 6, 2020
First Posted
February 10, 2020
Study Start
May 1, 2015
Primary Completion
June 1, 2016
Study Completion
May 1, 2017
Last Updated
February 10, 2020
Record last verified: 2020-02