Anesthesia and Cancer Study: Colon Cancer
The Influence of Type of Anesthesia on Mortality and Cancer Recurrence After Colon Cancer Surgery: Multi-center Prospective Randomized Controlled Study
1 other identifier
interventional
797
1 country
2
Brief Summary
This study investigates the influence of type of anesthesia on survival and recurrence rate in patients receiving colon cancer surgery. The participants will be allocated to either the TIVA group and the inhalation group.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for not_applicable
Started Feb 2020
Longer than P75 for not_applicable
2 active sites
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
February 4, 2020
CompletedFirst Posted
Study publicly available on registry
February 6, 2020
CompletedStudy Start
First participant enrolled
February 18, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
May 3, 2028
ExpectedStudy Completion
Last participant's last visit for all outcomes
May 3, 2028
November 22, 2023
November 1, 2023
8.2 years
February 4, 2020
November 20, 2023
Conditions
Keywords
Outcome Measures
Primary Outcomes (1)
five year survival
survival rate regardless of recurrence
five years survival
Secondary Outcomes (5)
five year recurrence free survival
five years after surgery
1 year recurrence free survival
1 year after surgery
3 year recurrence free survival
3 years after surgery
1 year survival
1 year after surgery
3 year survival
3 years after surgery
Study Arms (2)
TIVA
EXPERIMENTALpropofol infusion targeting bispectral index 40-60
inhalation (Sevoflurane)
ACTIVE COMPARATORsevoflurane targeting bispectral index 40-60
Interventions
propofol 1-2 mg/kg bolus injection for induction of anesthesia propofol continuous infusion for maintenance of anesthesia
sevoflurane is administered for induction and maintenance of anesthesia
Eligibility Criteria
You may qualify if:
- adults undergoing surgery to remove colon cancer
You may not qualify if:
- pregnancy
- colon cancer with invasion to perineum
- palliative surgery
- history of diagnosis or surgery for other cancer
- emergent surgery
- ASA PS classification 4 and 5
- refusion to participate in the study
- allergy to anesthetics
Contact the study team to confirm eligibility.
Sponsors & Collaborators
- Seoul National University Hospitallead
- Korean Society of Anesthesiologistscollaborator
- Seoul National University Bundang Hospitalcollaborator
- Chung-Ang University Hosptial, Chung-Ang University College of Medicinecollaborator
- Seoul St. Mary's Hospitalcollaborator
- Seoul National University Boramae Hospitalcollaborator
Study Sites (2)
Seoul Metropolitan Government Seoul National University Boramae Medical Center
Seoul, 07061, South Korea
Seoul National University Hospital
Seoul, 110-744, South Korea
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Study Design
- Study Type
- interventional
- Phase
- not applicable
- Allocation
- RANDOMIZED
- Masking
- DOUBLE
- Who Masked
- PARTICIPANT, OUTCOMES ASSESSOR
- Purpose
- PREVENTION
- Intervention Model
- PARALLEL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Professor (full)
Study Record Dates
First Submitted
February 4, 2020
First Posted
February 6, 2020
Study Start
February 18, 2020
Primary Completion (Estimated)
May 3, 2028
Study Completion (Estimated)
May 3, 2028
Last Updated
November 22, 2023
Record last verified: 2023-11
Data Sharing
- IPD Sharing
- Will not share