NCT03561831

Brief Summary

Investigate the change in endoplasmic reticulum stress after cancer surgery according to different anaesthetics including propofol and sevoflurane.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
53

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Jun 2018

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

June 4, 2018

Completed
1 day until next milestone

Study Start

First participant enrolled

June 5, 2018

Completed
14 days until next milestone

First Posted

Study publicly available on registry

June 19, 2018

Completed
11 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 29, 2019

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 29, 2019

Completed
Last Updated

October 15, 2021

Status Verified

October 1, 2021

Enrollment Period

12 months

First QC Date

June 4, 2018

Last Update Submit

October 14, 2021

Conditions

Endoplasmic Reticulum Stress

Outcome Measures

Primary Outcomes (1)

  • Change in endoplasmic reticulum stress

    Change in endoplasmic reticulum stress

    baseline, postoperative 1 hours and 24 hours

Study Arms (2)

propofol group

ACTIVE COMPARATOR

patients who anesthesized by propofol

Drug: Propofol

sevoflurane group

ACTIVE COMPARATOR

patients who anesthesized by sevoflurane

Drug: Sevoflurane

Interventions

PropofolDRUG

propofol based anesthesia

propofol group
SevofluraneDRUG

sevoflurane based anesthesia

sevoflurane group

Eligibility Criteria

Age20 Years+
Sexfemale
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • \- patients with cancer

You may not qualify if:

  • age under 19 years old
  • allergy history to propofol or sevoflurane
  • history of previous cancer

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Konkuk University Medical Center

Seoul, 05030, South Korea

Location

MeSH Terms

Interventions

PropofolSevoflurane

Intervention Hierarchy (Ancestors)

PhenolsBenzene DerivativesHydrocarbons, AromaticHydrocarbons, CyclicHydrocarbonsOrganic ChemicalsMethyl EthersEthersHydrocarbons, FluorinatedHydrocarbons, Halogenated

Study Officials

  • Seong-Hyop Kim, Professor

    Konkuk University Medical Center

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
QUADRUPLE
Who Masked
PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
BASIC SCIENCE
Intervention Model
FACTORIAL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

June 4, 2018

First Posted

June 19, 2018

Study Start

June 5, 2018

Primary Completion

May 29, 2019

Study Completion

May 29, 2019

Last Updated

October 15, 2021

Record last verified: 2021-10

Data Sharing

IPD Sharing
Will not share

Locations

KR(1)