NCT04258904

Brief Summary

A Cluster-controlled Intervention Trial regarding Prevention of Dermatological Complications towards use of Continuous glucose monitoring and insulin pumps in pediatric patients with Type 1 Diabetes. The patients will be followed prospectively with visits every 3rd month for the first year of initiation of device. Besides a standardized treatment plan if dermatological complications evolve, will be used.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
236

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Mar 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 28, 2020

Completed
9 days until next milestone

First Posted

Study publicly available on registry

February 6, 2020

Completed
1 month until next milestone

Study Start

First participant enrolled

March 10, 2020

Completed
2.5 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

September 20, 2022

Completed
2 months until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2022

Completed
Last Updated

December 7, 2022

Status Verified

December 1, 2022

Enrollment Period

2.5 years

First QC Date

January 28, 2020

Last Update Submit

December 6, 2022

Conditions

Keywords

Type 1 Diabetes

Outcome Measures

Primary Outcomes (1)

  • Incidence of dermatological complications

    Dermatological complications towards the devices will be assessed by clinical examination made by the investigator at visits every 3rd month and using a standardized scheme combined with self-reporting from the patients through diary forms if dermatological complications arise between visits. The incidence of dermatological complications through the time frame will be reported as primary outcome.

    Up to 12 months after inclusion

Secondary Outcomes (1)

  • Trans Epidermal Water Loss (TEWL):

    Up to 12 months after inclusion

Study Arms (2)

Intervention

EXPERIMENTAL

Skin Care Program

Combination Product: Skin Care Program

Control

NO INTERVENTION

Usual Treatment

Interventions

Skin Care ProgramCOMBINATION_PRODUCT

The intervention consists of a Skin Care Program including neat information regarding dermatological complications to the device use, prevention of these and moisturizer to keep healthy skin.

Intervention

Eligibility Criteria

Age2 Years - 20 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Diagnosed with Type 1 Diabetes
  • Initiating either Insulin pump, Flash glucose monitorer or continuous glucose monitor

You may not qualify if:

  • \*Language difficulties regarding Danish

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Department of Pediatrics, Herlev Hospital

Herlev, 2730, Denmark

Location

Related Publications (1)

  • Sorensen FMW, Svensson J, Kinnander C, Berg AK. Ultrasound Detected Subcutaneous Changes in a Pediatric Cohort After Initiation of a New Insulin Pump or Glucose Sensor. Diabetes Technol Ther. 2023 Sep;25(9):622-630. doi: 10.1089/dia.2023.0137. Epub 2023 Jun 6.

MeSH Terms

Conditions

Diabetes Mellitus, Type 1

Condition Hierarchy (Ancestors)

Diabetes MellitusGlucose Metabolism DisordersMetabolic DiseasesNutritional and Metabolic DiseasesEndocrine System DiseasesAutoimmune DiseasesImmune System Diseases

Study Officials

  • Jannet Svensson

    Department of Pediatrics, Herlev and Gentofte Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NON RANDOMIZED
Masking
NONE
Purpose
PREVENTION
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
MD, PhD, Assistant Professor

Study Record Dates

First Submitted

January 28, 2020

First Posted

February 6, 2020

Study Start

March 10, 2020

Primary Completion

September 20, 2022

Study Completion

November 30, 2022

Last Updated

December 7, 2022

Record last verified: 2022-12

Data Sharing

IPD Sharing
Will not share

Locations