Acute Effects of Vigorous-intensity Aerobic Exercise on Glymphatic Flow in Healthy Adults

NCT04255758 | Unknown

• 1 other identifier: T6/2020
• Study Type: interventional
• Target: 20
• Locations: 1 country
• Sites: 1

Brief Summary

This study investigates changes in glymphatic flow in the brain acutely after vigorous-intensity steady-state aerobic exercise. Twenty subjects (10 male and 10 female) perform 25 minute submaximal cycle ergometry exercise and the changes in the glymphatic flow and cerebral perfusion are evaluated using a variety of MRI sequences (e.g. MREG).

Conditions

Glymphatic System; Neurodegeneration

Keywords

glymphatic system; cerebral perfusion; aerobic exercise

Outcome Measures

Primary Outcomes (1)

• MREG cardiovascular pulse wavefront

  Is processed into three-dimensional vector fields and used as an assessment of glymphatic flow, scanned once before and multiple times after exercise intervention in 5-minute sequences

  3 hours

Secondary Outcomes (3)

• Cerebral perfusion fMRI

  3 hours

• Heart rate (HR)

  3 hours

• Blood pressure (BP)

  3 hours

Study Arms (1)

Vigorous-intensity Aerobic Exercise

EXPERIMENTAL

Vigorous-intensity aerobic exercise, single intervention

Other: Cycle Ergometer Exercise

Interventions

Cycle Ergometer Exercise OTHER

25 minutes, 70% VO2max steady state cycle ergometry exercise

Vigorous-intensity Aerobic Exercise

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Age 18-45
• BMI 18-30
• Resting Blood pressure \< 140/90 mmHg

You may not qualify if:

• History of a cardiac event
• Insulin or medically treated diabetes
• Any chronic disease or condition that could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
• Presence of ferromagnetic objects that would make MR imaging contraindicated
• Claustrophobia
• Abundant use of alcohol
• Use of narcotics
• Smoking of tobacco or consuming snuff tobacco
• Diagnosed depressive or bipolar disorder
• Abnormalities in resting ECG (revised by the study physician)
• Pregnancy

Sponsors & Collaborators

• Turku University Hospital: lead

Study Sites (1)

Turku PET Centre

Turku, 20521, Finland

RECRUITING

Related Publications (2)

• Rajna Z, Raitamaa L, Tuovinen T, Heikkila J, Kiviniemi V, Seppanen T. 3D Multi-Resolution Optical Flow Analysis of Cardiovascular Pulse Propagation in Human Brain. IEEE Trans Med Imaging. 2019 Sep;38(9):2028-2036. doi: 10.1109/TMI.2019.2904762. Epub 2019 Mar 15.

  PMID: 30892202 BACKGROUND

• von Holstein-Rathlou S, Petersen NC, Nedergaard M. Voluntary running enhances glymphatic influx in awake behaving, young mice. Neurosci Lett. 2018 Jan 1;662:253-258. doi: 10.1016/j.neulet.2017.10.035. Epub 2017 Oct 25.

  PMID: 29079431 BACKGROUND

MeSH Terms

Conditions

Nerve Degeneration

Condition Hierarchy (Ancestors)

Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Ilkka Heinonen, PhD

  Turku PET Centre

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Ilkka Heinonen, PhD

CONTACT

+358 408 393 962; ilkka.heinonen@utu.fi

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER GOV
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Adjunct Professor, Department of Clinical Medicine

Model Details: Prospective interventional study model, all subjects undergo the same exercise intervention and results are compared to baseline values

Study Record Dates

• First Submitted: February 3, 2020
• First Posted: February 5, 2020
• Study Start: February 8, 2021
• Primary Completion: December 31, 2021
• Study Completion: December 31, 2021
• Last Updated: February 11, 2021

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

FI (1)