Composition of Meals Around Exercise Session

NCT04249609 | Completed

• 1 other identifier: 200180122
• Study Type: interventional
• Target: 14
• Locations: 1 country
• Sites: 1

Brief Summary

This will be a randomised cross-over study where participants will be asked to undergo screening session followed by submaximal exercise test and then undergo 2 experimental trials, one high CHO trial and another high fat trial, each lasting over 2 days. On Day 1 participants will consume either high CHO or high fat evening meal and on Day 2 they will be exercising for 60 minutes in the fasted state and then consume either high CHO or high fat morning meal and then 5 hours after morning meal ad libitum buffet meal. After this, they will leave metabolic investigation room and will record all food and drinks consumed during the rest of the day. The washout period between the trials will be at least 7 days. Prior to each of the experimental trials, participants will be asked to avoid consumption of coffee and alcohol for the duration of 2 days. All data collection will all take place in the metabolic research unit at New Lister Building (NLB), Glasgow Royal infirmary (GRI).

Conditions

Gastrointestinal Hormones

Keywords

Exercise; Appetite; Gastrointestinal hormones; Macronutrient; Fat oxidation; Thermic effect of food; Energy intake

Outcome Measures

Primary Outcomes (3)

• Appetite Hormones: Glucagon like peptide (GLP-1)

  Plasma concentration during HCHO and LCHO trials

  420 minutes through study completion, an average of 10 days

• Appetite Hormone: Peptide YY (PYY)

  Plasma concentration during HCHO and LCHO trials

  420 minutes through study completion, an average of 10 days

• Growth Differentiation Factor-15 (GDF 15)

  Plasma concentration during HCHO and LCHO trials

  420 minutes through study completion, an average of 10 days

Secondary Outcomes (7)

• Insulin

  420 minutes through study completion, an average of 10 days

• Glucose

  420 minutes through study completion, an average of 10 days

• Triglycerides

  420 minutes through study completion, an average of 10 days

• Subjective appetite scores

  420 minutes through study completion, an average of 10 days

• Diet induced thermogenesis

  420 minutes through study completion, an average of 10 days

Study Arms (2)

High Carbohydrate Meals Around Exercise

EXPERIMENTAL

On day 1, high CHO dinner meal will provide 35% of participants total daily energy requirements. Meal will consist of pasta, meat ball and orange juice. On the day 2, participants will exercise for 60 minutes and then in 60 minutes will consume morning meal, providing 30% of their total daily energy requirements. Morning meal will consist of oats, skimmed-milk, banana and seedless raisins.

Other: HCHO meals and exercise

Low Carbohydrate Meals Around Exercise

EXPERIMENTAL

On day 1, low CHO dinner meal will provide 35% of participants total daily energy requirements. Meal will based on burger, cheese, mushroom, nuts, and butter.On the day 2, participants will exercise fro 60 minutes and then in 60 will consume morning meal, providing 30% of their total daily energy requirements. Meal will consist of white bread, egg, cheese, olive oil, nuts, and olives.

Other: LCHO meals and exercise

Interventions

HCHO meals and exercise OTHER

Exercise will be conducted after high carbohydrate dinner and prior to high carbohydrate breakfast

Also known as: High carbohydrate meals and exercise

High Carbohydrate Meals Around Exercise

LCHO meals and exercise OTHER

Exercise will be conducted after high fat dinner and prior to high fat breakfast

Also known as: Low Carbohydrate and exercise Intervention

Low Carbohydrate Meals Around Exercise

Eligibility Criteria

• Age: 25 Years - 35 Years
• Sex: male
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Healthy sedentary males aged between 25-35 years with body mass index (BMI) 25- 30 kg/m2
• participants with stable body weight for at least 3 months.

You may not qualify if:

• Smokers, suffering from food allergy, on any dietary supplements or dietary regimes at the time of the study
• Participants with systolic/diastolic \<90/60 mmHg and \>140/90 mmHg or with history of chronic illness.

Sponsors & Collaborators

• University of Glasgow: lead

Study Sites (1)

Human Nutrition, College of Medicine, Veterinary and Life Science

Glasgow, G31 2ER, United Kingdom

Location

MeSH Terms

Conditions

Motor Activity

Interventions

Exercise

Condition Hierarchy (Ancestors)

Behavior

Intervention Hierarchy (Ancestors)

Motor Activity; Movement; Musculoskeletal Physiological Phenomena; Musculoskeletal and Neural Physiological Phenomena

Study Officials

• Dalia Malkova, PhD

  University of Glasgow

  STUDY CHAIR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr Dalia Malkova Senior Lecture in Human Nutrition, School of Medicine, Dentistry & Nursing

Study Record Dates

• First Submitted: November 1, 2019
• First Posted: January 31, 2020
• Study Start: April 23, 2019
• Primary Completion: June 2, 2022
• Study Completion: August 5, 2022
• Last Updated: August 1, 2023

Record last verified: 2023-07

Locations

GB (1)