The Effect of Macronutrient Composition of Meals Consumed Around a Single Exercise Session of Subjective Appetite, Appetite Hormones and Daily Energy Intake in Overweight Men
Sponsor study identifier
interventional
14
1 country
1
Study Start
April 23, 2019
Actual (reported)Primary Completion
June 2, 2022
Actual (reported)Study Completion
August 5, 2022
Actual (reported)This will be a randomised cross-over study where participants will be asked to undergo screening session followed by submaximal exercise test and then undergo 2 experimental trials, one high CHO trial and another high fat trial, each lasting over 2 days. On Day 1 participants will consume either high CHO or high fat evening meal and on Day 2 they will be exercising for 60 minutes in the fasted state and then consume either high CHO or high fat morning meal and then 5 hours after morning meal ad libitum buffet meal. After this, they will leave metabolic investigation room and will record all food and drinks consumed during the rest of the day. The washout period between the trials will be at least 7 days. Prior to each of the experimental trials, participants will be asked to avoid consumption of coffee and alcohol for the duration of 2 days. All data collection will all take place in the metabolic research unit at New Lister Building (NLB), Glasgow Royal infirmary (GRI).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
August 5, 2022
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
April 23, 2019
Actual (reported)November 1, 2019
Actual (reported)January 31, 2020
Actual (reported)June 2, 2022
Actual (reported)August 5, 2022
Actual (reported)Appetite Hormones: Glucagon like peptide (GLP-1)
Plasma concentration during HCHO and LCHO trials
420 minutes through study completion, an average of 10 days
Appetite Hormone: Peptide YY (PYY)
Plasma concentration during HCHO and LCHO trials
420 minutes through study completion, an average of 10 days
Growth Differentiation Factor-15 (GDF 15)
Plasma concentration during HCHO and LCHO trials
420 minutes through study completion, an average of 10 days
Insulin
420 minutes through study completion, an average of 10 days
Glucose
420 minutes through study completion, an average of 10 days
Triglycerides
420 minutes through study completion, an average of 10 days
Subjective appetite scores
420 minutes through study completion, an average of 10 days
Diet induced thermogenesis
420 minutes through study completion, an average of 10 days
On day 1, high CHO dinner meal will provide 35% of participants total daily energy requirements. Meal will consist of pasta, meat ball and orange juice. On the day 2, participants will exercise for 60 minutes and then in 60 minutes will consume morning meal, providing 30% of their total daily energy requirements. Morning meal will consist of oats, skimmed-milk, banana and seedless raisins.
On day 1, low CHO dinner meal will provide 35% of participants total daily energy requirements. Meal will based on burger, cheese, mushroom, nuts, and butter.On the day 2, participants will exercise fro 60 minutes and then in 60 will consume morning meal, providing 30% of their total daily energy requirements. Meal will consist of white bread, egg, cheese, olive oil, nuts, and olives.
Exercise will be conducted after high carbohydrate dinner and prior to high carbohydrate breakfast
Exercise will be conducted after high fat dinner and prior to high fat breakfast
Human Nutrition, College of Medicine, Veterinary and Life Science
Glasgow, G31 2ER, United Kingdom
Dalia Malkova, PhD
University of Glasgow
14 participants (actual enrollment reported by the registry).
First Submitted
November 1, 2019
First Posted
January 31, 2020
Study Start
April 23, 2019
Actual (reported)Effects of Oral Xylitol on Subsequent Energy Intake
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Primary Completion
June 2, 2022
Actual (reported)Study Completion
August 5, 2022
Actual (reported)Last Updated
August 1, 2023
Record last verified: 2023-07
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Source: ClinicalTrials.gov.
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