Urinary Tract Infection in Pregnancy
Distribution of Virulence Genes and Their Association With Clinical Presentation of Urinary Tract Infection and Antimicrobial Resistance Among Uropathogenic Escherichia Coli Isolated From Pregnant Women
1 other identifier
observational
155
0 countries
N/A
Brief Summary
- to describe the profile of uropathogenic E coli from Egyptian pregnant women with UTIs and a symptomatic bacteriuria.
- to determine the susceptibility pattern of our local isolated UPEC strains which is essential for optimal management of UTI.
- to evaluate the different virulence genes in UPEC isolates and their association with antibiotic resistance.
- to track common UPEC serogroups.
- to investigate the biofilm formation and the relationship between virulence genes and biofilm formation in UPEC strains isolated from patients.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P50-P75 for all trials
Started Mar 2020
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
First Submitted
Initial submission to the registry
January 25, 2020
CompletedFirst Posted
Study publicly available on registry
January 28, 2020
CompletedStudy Start
First participant enrolled
March 1, 2020
CompletedPrimary Completion
Last participant's last visit for primary outcome
March 1, 2021
CompletedStudy Completion
Last participant's last visit for all outcomes
May 1, 2021
CompletedJanuary 30, 2020
January 1, 2020
1 year
January 25, 2020
January 28, 2020
Conditions
Outcome Measures
Primary Outcomes (1)
The percentage of virulence genes in different isolated UPEC strains
Measurment of virulence genes of Escherichia coli strains by molecular diagnosis as PCR technique to determine relationship between clinical presentation of urinary tract infection and distribution of virulence genes of strains
Three months
Secondary Outcomes (1)
Correlation between the virulence genes and antibiotic resistance
Seven months
Study Arms (3)
Group1
Group 1:pregnant women with cystitis
Group2
Group 2: pregnant women with Pyelonephritis
Group3
Group 3: pregnant women with asymptomatic bacteriuria
Interventions
Eligibility Criteria
Pregnant women at different trimesters with cystitis and pyelonephritis and asymptomatic bacteriuria
You may qualify if:
- pregnant women who diagnosed through clinical examination and urine analysis. 3 groups : group 1 pregnant women with cystitis Group 2 pregnant women with Pyelonephritis Group 3 pregnant women with asymptomatic bacteriuria
You may not qualify if:
- pregnant women on antibiotics \_Patients with any anatomical abnormalities in the urinary tract
Contact the study team to confirm eligibility.
Sponsors & Collaborators
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- CASE ONLY
- Time Perspective
- CROSS SECTIONAL
- Sponsor Type
- OTHER
- Responsible Party
- PRINCIPAL INVESTIGATOR
- PI Title
- Demonstrator of medical microbiology and immunology. Faculty of medicine. Assiut university
Study Record Dates
First Submitted
January 25, 2020
First Posted
January 28, 2020
Study Start
March 1, 2020
Primary Completion
March 1, 2021
Study Completion
May 1, 2021
Last Updated
January 30, 2020
Record last verified: 2020-01