Effects of Mirror Therapy and Bilateral Arm Training on Hemiparetic Upper Extremity in Patients With Chronic Stroke

NCT04242316 | Completed

• 1 other identifier: HSEARS20121012008
• Study Type: interventional
• Target: 101
• Locations: 0 countries
• Sites: N/A

Brief Summary

The aim of this study included (1) to compare the effectiveness of mirror therapy (MT) and bimanual arm training (BAT) in improving motor and functional performance of hemiplegic upper extremity for adults with chronic stroke; (2) to examine whether recruitment of the mirror neurons, as reflected in mu rhythm suppression, mediates recognition of the mirror illusion in pre/post MT, as compared to BAT without a mirror in clients with chronic stroke, as compared to healthy participants.

Conditions

Stroke; Hemiplegia

Keywords

Stroke; Mirror therapy; Bilateral arm training; Upper limb function

Outcome Measures

Primary Outcomes (3)

• Fugl-Meyer assessment (FMA)

  FMA-UE is a standard upper limb motor impairment assessment for stroke survivors. FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.

  Baseline

• Fugl-Meyer assessment (FMA)

  FMA-UE is a standard upper limb motor impairment assessment for stroke survivors. FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.

  After 6-week

• Fugl-Meyer assessment (FMA)

  FMA-UE is a standard upper limb motor impairment assessment for stroke survivors. FMA-UE assesses voluntary movement, reflex activity, grasp and coordination.

  3-month after the completion of training

Secondary Outcomes (6)

• Action Research Arm Test (ARAT)

  Baseline

• Action Research Arm Test (ARAT)

  After 6-week

• Action Research Arm Test (ARAT)

  3-month after the completion of training

• Wolf Motor Function Test (WMFT)

  Baseline

• Wolf Motor Function Test (WMFT)

  After 6-week

Other Outcomes (2)

• Mu rhythm suppression generated in the sensorimotor cortex

  Baseline

• Mu rhythm suppression generated in the sensorimotor cortex

  6-week

Study Arms (2)

Mirror Therapy

EXPERIMENTAL

Patients performed customized bimanual upper limb exercises with a mirror. They can observe the mirror visual feedback of their non-paretic hand during the movements.

Behavioral: Mirror Therapy

Bilateral arm training

ACTIVE COMPARATOR

Patients performed customized bimanual upper limb exercises without a mirror.

Behavioral: Bilateral arm training

Interventions

Mirror Therapy BEHAVIORAL

Patients performed customized bimanual upper limb exercises with graded level of difficulty based on the patient's individual levels of upper limb functioning according to the 7 levels of the FTHUE and each level consisted of 5 standardized table-top tasks. The patients practiced the movements with the unaffected hand (including the shoulder, elbow, wrist, and hand). While watching the reflection of the unaffected hand in the mirror, the patient was then asked to moving the affected hand at the same time to synchronize the movement with the reflection of the unaffected hand. If the patient was unable to move the hand, a therapist would passively assist the movement of the affected hand so as to synchronize it with the reflection of the unaffected hand.

Mirror Therapy

Bilateral arm training BEHAVIORAL

Patients performed customized bimanual upper limb exercises with graded level of difficulty based on the patient's individual levels of upper limb functioning according to the 7 levels of the FTHUE and each level consisted of 5 standardized table-top tasks, but without a mirror. The patients can take a direct view of their paretic hand.

Bilateral arm training

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• neurological condition with unilateral hemiparesis;
• a Functional Test of Hemiplegic Upper Extremity (FTHUE) score between levels 2 to 6;
• chronic stroke with onset of neurological condition more than 6 months previously;
• ability to understand and follow simple verbal instructions;
• ability to participate in a therapy session lasting at least 30 minutes;
• community ambulant with or without aids.

You may not qualify if:

• Individuals with severe neglect and severe spasticity (Modified Ashworth Scale \>3) would be excluded.

Sponsors & Collaborators

• The Hong Kong Polytechnic University: lead

MeSH Terms

Conditions

Stroke; Hemiplegia

Interventions

Mirror Movement Therapy

Condition Hierarchy (Ancestors)

Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Paralysis; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Intervention Hierarchy (Ancestors)

Physical Therapy Modalities; Rehabilitation; Therapeutics

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 22, 2020
• First Posted: January 27, 2020
• Study Start: January 1, 2014
• Primary Completion: January 1, 2017
• Study Completion: January 1, 2019
• Last Updated: January 27, 2020

Record last verified: 2020-01

Data Sharing

• IPD Sharing: Will not share