Prospective Longitudinal Observational Research in Atopic Dermatitis

NCT04240522 | Recruiting DMC

• 1 other identifier: ProRaD
• Study Type: observational
• Target: 1,000
• Locations: 1 country
• Sites: 1

Brief Summary

Atopic dermatitis (AD) is a frequent chronic relapsing inflammatory skin disorder, characterized by intensely itchy eczema. AD usually starts within the first 2 years of life. In 30 - 60% of children, inflammation spreads onto other body surfaces such as the gastrointestinal tract, the respiratory tract, and the conjunctives within a few years. This sequence is called atopic march. Atopic dermatitis and associated atopic diseases are more frequent in families, suggesting a genetic predisposition. However, the underlying factors such as genetic phenotype, environmental factors, or life style which cause or worsen an existing allergic disease are not understood yet. Affected people suffer from recurrent flares that result in significantly impaired quality. This study will collect clinical and laboratory data to elucidate immunotolerance and preventiv stategies with the aim to develop new and individual treatment options of atopic diseases.

Conditions

Atopic Dermatitis; Asthma; Atopic Dermatitis and Related Conditions

Keywords

Eczema; Dermatitis; Atopy

Outcome Measures

Primary Outcomes (1)

• Remission of atopic dermatitis and associated allergic diseases

  Prospective observational study

  5 years

Secondary Outcomes (2)

• Endogenous and exgogenouse factors that influence and predict the course of AD.

  5 years

• Identification of potential biomarkers predicting the course of AD

  5 years

Eligibility Criteria

• Age: 1 Year - 85 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients with atopic dermatits, any other allergic diseases and /or healthy controls

You may qualify if:

• Age 0 - 85 years
• Diagnosis of AD and/or another disease of the atopic group (i.e. allergic rhinitis, allergic asthma, food allergy)
• Age 0 - 85 years
• No diagnosis or history of allergic disease
• Written consent will be obtained after detailed information of the study was given to the participant.

You may not qualify if:

• \- Unable to give consent or refusal to participate in the study

Sponsors & Collaborators

• University of Zurich: lead
• University of Bonn: collaborator

Study Sites (1)

Allergy Unit, Dept. of Dermatology, Unviersity Hosptial of Zurich

Zurich, Canton of Zurich, 8091, Switzerland

RECRUITING

Biospecimen

Retention: SAMPLES WITH DNA

serum samples, Microbiom swabs Ski biopsy (selcted cases)

MeSH Terms

Conditions

Dermatitis, Atopic; Asthma; Eczema; Dermatitis

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases; Bronchial Diseases; Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Respiratory Hypersensitivity

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 20, 2020
• First Posted: January 27, 2020
• Study Start: April 4, 2017
• Primary Completion (Estimated): March 30, 2031
• Study Completion (Estimated): March 30, 2031
• Last Updated: February 5, 2026

Record last verified: 2026-02

Locations

CH (1)