The Natural History of Atopic Disease in Thai Children and Association With Atopic March

NCT02532920 | Completed DMC

• 1 other identifier: 715/2557(EC4)
• Study Type: observational
• Target: 102
• Locations: 1 country
• Sites: 1

Brief Summary

Atopic dermatitis(AD) is one of manifestation in atopic march. The prevalence of AD is increased. In 1998, the investigators found the prevalence of AD about 15 % in Thailand. AD is diagnosed by clinical as Hanifin and Rajka criteria. There are 3 group of severity defined by SCORAD(Scoring Atopic Dermatitis) : mild (\<25), moderate (25-50) and severe (\>50). The natural history of AD was mentioned in 3 groups: complete remission, persistent and intermittent. Atopic march is the progression of atopic disease that has atopic dermatitis as the first manifestation then patients will have allergic rhinitis or asthma in the future. The investigators do a retrospective study to understand the natural history of AD as well as it associate with atopic march. That might be a predictive factor of AD and atopic march

Conditions

Atopic Dermatitis

Keywords

Natural history; Atopic dermatitis; Atopic march

Outcome Measures

Primary Outcomes (1)

• To evaluate the natural history of atopic dermatitis in Thai children and the factors that could be associate with the progression of the disease.

  complete remission (no AD rash and no topical steroid (TS) or topical tacrolimus (TT) use more than one year), persistent (use TS/TT once a month to control AD) and intermittent (other than two groups)

  Recruited the AD patient who was diagnosed between at birth until 15 years old. The following time at allergy clinic about 4 years in average.

Secondary Outcomes (1)

• The association of atopic dermatitis and atopic march.

  At the first diagnosis of atopic dermatitis until current Allergic visit or telephone interview.The following time at allergy clinic about 4 years in average.

Study Arms (1)

Atopic dermatitis

Atopic dermatitis is diagnosis as Hanifin and Rajka from physician.

Eligibility Criteria

• Age: Up to 15 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)
• Sampling Method: Probability Sample

Study Population

Patient who was diagnosed with atopic dermatitis by physician by searching ICD 10(L20.9, L20.8)

You may qualify if:

• Diagnosis of AD by physician at birth-15 years old
• Diagnosed by physician by Hanifin and Rajka criteria: itching, dry skin, chronic dermatitis : at face, extensor area (infant), flexor area (children and adult), with or with out history of atopy in family
• Follow at allergy clinic once a year or can ask current symptom via telephone interview.
• Evaluate severity of the disease by SCORAD (Scoring Atopic Dermatitis )

You may not qualify if:

• Onset of atopic dermatitis more than 15 years old.
• Other disease: skin, cardiovascular, liver disease, endocrine, neurology, ect
• Not complete data collection in case record form in out patient record.
• Cannot be reach current symptom of patient.

Sponsors & Collaborators

• Mahidol University: lead

Study Sites (1)

Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, Bangkok, 10700, Thailand

Location

Related Publications (8)

• Nicol NH, Boguniewicz M, Strand M, Klinnert MD. Wet wrap therapy in children with moderate to severe atopic dermatitis in a multidisciplinary treatment program. J Allergy Clin Immunol Pract. 2014 Jul-Aug;2(4):400-6. doi: 10.1016/j.jaip.2014.04.009.

  PMID: 25017527 RESULT

• Odhiambo JA, Williams HC, Clayton TO, Robertson CF, Asher MI; ISAAC Phase Three Study Group. Global variations in prevalence of eczema symptoms in children from ISAAC Phase Three. J Allergy Clin Immunol. 2009 Dec;124(6):1251-8.e23. doi: 10.1016/j.jaci.2009.10.009.

  PMID: 20004783 RESULT

• Chung Y, Kwon JH, Kim J, Han Y, Lee SI, Ahn K. Retrospective analysis of the natural history of atopic dermatitis occurring in the first year of life in Korean children. J Korean Med Sci. 2012 Jul;27(7):723-8. doi: 10.3346/jkms.2012.27.7.723. Epub 2012 Jun 29.

  PMID: 22787365 RESULT

• Vichyanond P, Jirapongsananuruk O, Visitsuntorn N, Tuchinda M. Prevalence of asthma, rhinitis and eczema in children from the Bangkok area using the ISAAC (International Study for Asthma and Allergy in Children) questionnaires. J Med Assoc Thai. 1998 Mar;81(3):175-84.

  PMID: 9623008 RESULT

• Severity scoring of atopic dermatitis: the SCORAD index. Consensus Report of the European Task Force on Atopic Dermatitis. Dermatology. 1993;186(1):23-31. doi: 10.1159/000247298.

  PMID: 8435513 RESULT

• Shaker M. New insights into the allergic march. Curr Opin Pediatr. 2014 Aug;26(4):516-20. doi: 10.1097/MOP.0000000000000120.

  PMID: 24886953 RESULT

• Illi S, von Mutius E, Lau S, Nickel R, Gruber C, Niggemann B, Wahn U; Multicenter Allergy Study Group. The natural course of atopic dermatitis from birth to age 7 years and the association with asthma. J Allergy Clin Immunol. 2004 May;113(5):925-31. doi: 10.1016/j.jaci.2004.01.778.

  PMID: 15131576 RESULT

• Wisniewski JA, Agrawal R, Minnicozzi S, Xin W, Patrie J, Heymann PW, Workman L, Platts-Mills TA, Song TW, Moloney M, Woodfolk JA. Sensitization to food and inhalant allergens in relation to age and wheeze among children with atopic dermatitis. Clin Exp Allergy. 2013 Oct;43(10):1160-70. doi: 10.1111/cea.12169.

  PMID: 24074334 RESULT

MeSH Terms

Conditions

Dermatitis, Atopic

Condition Hierarchy (Ancestors)

Skin Diseases, Genetic; Genetic Diseases, Inborn; Congenital, Hereditary, and Neonatal Diseases and Abnormalities; Dermatitis; Skin Diseases; Skin and Connective Tissue Diseases; Skin Diseases, Eczematous; Hypersensitivity, Immediate; Hypersensitivity; Immune System Diseases

Study Officials

• Orathia Piboonpocanun, professor

  Siriraj Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: ECOLOGIC OR COMMUNITY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Division of Allergy and Immunology, Department of Pediatrics, Siriraj hospital

Study Record Dates

• First Submitted: August 20, 2015
• First Posted: August 26, 2015
• Study Start: January 1, 2015
• Primary Completion: June 1, 2016
• Study Completion: June 1, 2016
• Last Updated: September 22, 2016

Record last verified: 2016-09

Data Sharing

• IPD Sharing: Will not share

Locations

TH (1)