Eye Movement and Cognitive Dysfunction

NCT04236375 | Completed DMC

• 1 other identifier: Eye movement-cognitive decline
• Study Type: observational
• Target: 1,539
• Locations: 1 country
• Sites: 1

Brief Summary

There is association between eye movement disorder and cognitive dysfunction. Therefore, utilizing eye movement and screening for cognitive dysfunction is feasible. In the present study, the investigators will develop an artificial intelligence platform to screening for cognitive dysfunction by inspecting the function of eye movement. Futher more, based on the screening results, the platform will offer referral suggestions.

Conditions

Eye Movement Disorder; Cognitive Dysfunction

Outcome Measures

Primary Outcomes (1)

• Area under the curve

  AUC values for predicting whether subject has cognitive impairment or not

  up to 1 month

Secondary Outcomes (1)

• Accuracy, true positive rate, and true negetive rate

  up to 1 month

Study Arms (7)

Normal

Subjects over 45 years old without cognitive dysfunction

Mild cognitive decline

Subjects who are diagnosed as mild cognitive decline(MCI) according to neurologists.

Alzheimer's disease

Subjects who are diagnosed as Alzheimer's disease(AD) according to neurologists.

Vascular dementia

Subjects who are diagnosed as vascular dementia(VD) according to neurologists.

Lewy body dementia

Subjects who are diagnosed as Lewy body demenita (DLB) according to neurologists.

Frontotemporal dementia

Subjects who are diagnosed as Frontotemporal demenita (FD) according to neurologists.

Other dementia

Subjects who are diagnosed as dementia but are not as AD, VD, DLB OR FD.

Eligibility Criteria

• Age: 45 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Subjects who are over 45 years old with or without cognitive dysfunction.

You may qualify if:

• ①Subjects who are diagnosed as mild cognitive decline, Alzheimer's disease, Vascular dementia, Lewy body dementia, Frontotemporal dementia, other dementia and normal by neurologist.
• ②Subjects who can cooperate with the inspection.
• ③Subjects who agree to participate in the study and sign the consent form

You may not qualify if:

• ①Subjects who cannot do the inspection.
• ②Subjects who suffer from diseases that compromise the inspection.

Sponsors & Collaborators

• Sun Yat-sen University: lead

Study Sites (1)

Zhongshan Ophthalmic Center

Guangzhou, Guangdong, 510060, China

Location

MeSH Terms

Conditions

Ocular Motility Disorders; Cognitive Dysfunction

Condition Hierarchy (Ancestors)

Central Nervous System Diseases; Nervous System Diseases; Cranial Nerve Diseases; Eye Diseases; Cognition Disorders; Neurocognitive Disorders; Mental Disorders

Study Officials

• Haotian Lin, M.D.,Ph.D

  Zhongshan Ophthalmic Center, Sun Yat-sen University

  STUDY CHAIR

• Xun Wang, M.D.,Ph.D

  Zhongshan Ophthalmic Center, Sun Yat-sen University

  STUDY DIRECTOR

• Shuyi Zhang, M.D.

  Zhongshan Ophthalmic Center, Sun Yat-sen University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: CASE CROSSOVER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: January 18, 2020
• First Posted: January 22, 2020
• Study Start: September 1, 2020
• Primary Completion: July 30, 2025
• Study Completion: July 30, 2025
• Last Updated: April 13, 2026

Record last verified: 2020-01

Locations

CN (1)