NCT04236336

Brief Summary

This will be a prospective, randomized, observational study. All implants will be placed in either the maxilla or mandible and loaded within 2 months with a provisional or definitive prosthesis. The implants will be evaluated yearly for 2 years.

Trial Health

90
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
104

participants targeted

Target at P50-P75 for all trials

Timeline
Completed

Started Oct 2019

Longer than P75 for all trials

Geographic Reach
2 countries

5 active sites

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Start

First participant enrolled

October 1, 2019

Completed
4 months until next milestone

First Submitted

Initial submission to the registry

January 17, 2020

Completed
5 days until next milestone

First Posted

Study publicly available on registry

January 22, 2020

Completed
4.2 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

March 30, 2024

Completed
3 months until next milestone

Study Completion

Last participant's last visit for all outcomes

July 1, 2024

Completed
Last Updated

July 23, 2024

Status Verified

July 1, 2024

Enrollment Period

4.5 years

First QC Date

January 17, 2020

Last Update Submit

July 22, 2024

Conditions

Outcome Measures

Primary Outcomes (1)

  • Survival rate of implants at 2 years

    The average change in outcome (implant survival) from baseline (time of exposure or implant placement surgery) to the end of study (2 years) will be analyzed (at the implant level).

    2 years

Secondary Outcomes (1)

  • Crestal bone loss at 2 years

    2 years

Interventions

Qualified patient will be those patients who have been newly diagnosed with needing a dental implant (or more than one) in one or more edentulous areas in the maxilla and/or mandible.

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The patients selected will be considered exposed from the time of implant placement until the end of the study (2 years). All patients enrolled in this study will be included in the final analysis (whether complete study per protocol or not).

You may qualify if:

  • Patients of either sex and at least 18 years of age
  • Patients for whom a decision has already been made to use a dental implant for the restoration of existing edentulism in the mandible and/or maxilla.
  • Prior extracted sites or simultaneous extraction/ implant placement
  • Patients must be physically able to tolerate conventional surgical and restorative procedures.
  • Patients who provide a signed informed consent
  • Patients who agree to be evaluated for each study visit.

You may not qualify if:

  • Patients who are known to be pregnant at the screening visit or planning to become pregnant within 6 months of study enrollment.
  • Patients who have previously failed dental implants at the site intended for study implant placement
  • Patients with HIV or Hepatitis infection

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (5)

Louisiana State University-New Orleans

New Orleans, Louisiana, 70119, United States

Location

Dr. Amar Katranji

Ann Arbor, Michigan, 48108, United States

Location

Dr. Monish Bhola

Livonia, Michigan, 48150, United States

Location

Dr. Amar Katranji

Southfield, Michigan, 48034, United States

Location

Dr. Guillermo Pradies

Madrid, 28007, Spain

Location

MeSH Terms

Conditions

Jaw, Edentulous

Condition Hierarchy (Ancestors)

Jaw DiseasesMusculoskeletal DiseasesStomatognathic DiseasesMouth, EdentulousMouth DiseasesTooth Diseases

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Sponsor Type
INDUSTRY
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 17, 2020

First Posted

January 22, 2020

Study Start

October 1, 2019

Primary Completion

March 30, 2024

Study Completion

July 1, 2024

Last Updated

July 23, 2024

Record last verified: 2024-07

Data Sharing

IPD Sharing
Will not share

Locations