Correlation of Microvascular Ophthalmic Disease With Macrovascular Coronary Artery Disease in Trinidad

NCT04233619 | Completed

• 1 other identifier: CEC819/01/19
• Study Type: observational
• Target: 184
• Locations: 1 country
• Sites: 1

Brief Summary

Coronary artery disease (CAD) is the leading cause of death in Trinidad and Tobago. Early detection and management can help improve morbidity and mortality. Retinal artery microvascular disease has been shown to directly correlate with coronary artery disease. Retinal artery calibre screening via the Optic Coherence Tomography (OCT) will provide a non-invasive method of diagnosing CAD.

Conditions

Retinal Disease

Outcome Measures

Primary Outcomes (1)

• To determine if there is a direct correlation between retinal artery calibre and coronary artery disease

  Compare SYNTAX score and OCT results to determine correlation

  2 years

Interventions

optical coherence tomography DIAGNOSTIC_TEST

non-invasive test performed by an Ophthalmologist that allows three-dimensional imaging of the retinal vasculature

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Both male and female gender; all racial/ethnic groups including Afro-Caribbean, Indo-Caribbean, Asians, Caucasians, Hispanics and mixed ethnicities will be included in the study. Potential subjects will be identified from the Catheterization Lab at the Eric Williams Medical Sciences Complex. Patients who underwent or undergoing coronary angiography at the Eric Williams Medical Sciences Complex from May 1st 2019 to April 30th 2021.

You may qualify if:

• Patients 18 years and over,
• Patients who had a coronary angiogram done at the Catheterisation lab at the Eric Williams Medical Sciences Complex during the study period.

You may not qualify if:

• Patients who do not give informed consent to participate in the study,
• Patients who are acutely unwell,
• Patients who are symptomatic for Coronary Artery Disease,
• Patients with bilateral cataract.

Sponsors & Collaborators

• The University of The West Indies: lead

Study Sites (1)

The University of the West Indies

Saint Augustine, Trinidad and Tobago

Location

Related Publications (3)

• Yammine M, Itagaki S, Pawale A, Toyoda N, Reddy RC. SYNTAX score may predict the severity of atherosclerosis of the ascending aorta. J Thorac Dis. 2017 Oct;9(10):3859-3865. doi: 10.21037/jtd.2017.09.17.

  PMID: 29268395 BACKGROUND

• Michelson EL, Morganroth J, Nichols CW, MacVaugh H 3rd. Retinal arteriolar changes as an indicator of coronary artery disease. Arch Intern Med. 1979 Oct;139(10):1139-41.

  PMID: 485746 BACKGROUND

• Seecheran NA, Rafeeq S, Maharaj N, Swarath S, Seecheran V, Seecheran R, Seebalack V, Jagdeo CL, Seemongal-Dass R, Quert AYL, Giddings S, Ramlackhansingh A, Sandy S, Motilal S, Seemongal-Dass R. Correlation of RETINAL Artery Diameter with Coronary Artery Disease: The RETINA CAD Pilot Study-Are the Eyes the Windows to the Heart? Cardiol Ther. 2023 Sep;12(3):499-509. doi: 10.1007/s40119-023-00320-x. Epub 2023 Jun 15.

  PMID: 37318673 DERIVED

MeSH Terms

Conditions

Retinal Diseases

Interventions

Tomography, Optical Coherence

Condition Hierarchy (Ancestors)

Eye Diseases

Intervention Hierarchy (Ancestors)

Tomography, Optical; Optical Imaging; Diagnostic Imaging; Diagnostic Techniques and Procedures; Diagnosis; Tomography; Investigative Techniques

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 14, 2020
• First Posted: January 18, 2020
• Study Start: May 1, 2019
• Primary Completion: April 15, 2021
• Study Completion: April 15, 2021
• Last Updated: August 25, 2023

Record last verified: 2021-02

Data Sharing

• IPD Sharing: Will not share

Locations

TR (1)