NCT04225182

Brief Summary

The management of knee osteoarthritis via a physical activity protocol for rehabilitation has convincing results. However, the effectiveness of these protocols could be improved with a connected instrumented knee brace with an exercise protocol adapted for the patient which is supervise by an online physiotherapist to check the progression during home-based rehabilitation.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
65

participants targeted

Target at P50-P75 for not_applicable

Timeline
Completed

Started Jan 2020

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

January 7, 2020

Completed
6 days until next milestone

First Posted

Study publicly available on registry

January 13, 2020

Completed
9 days until next milestone

Study Start

First participant enrolled

January 22, 2020

Completed
2.4 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

June 2, 2022

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

June 2, 2022

Completed
Last Updated

March 24, 2026

Status Verified

March 1, 2026

Enrollment Period

2.4 years

First QC Date

January 7, 2020

Last Update Submit

March 20, 2026

Conditions

Outcome Measures

Primary Outcomes (1)

  • Change External Knee Moment Abduction (EKAM) during gait cycle from baseline at 8 weeks after rehabilitation

    Assessment of knee external knee moment abduction

    At the baseline (inclusion) and after 8 weeks of muscular strengthening

Study Arms (2)

with instrumented Orthosis

EXPERIMENTAL

patient will follow 8 weeks of muscular strengthening with the orthosis connected to the phone app associated

Device: with instrumented Orthosis

without instrumented Orthosis

ACTIVE COMPARATOR

patient will follow 8 weeks of traditional muscular strengthening without orthosis

Device: traditional rehabilitation protocol

Interventions

muscular strengthening protocol with traditional rehabilitation protocol without orthosis

without instrumented Orthosis

8 weeks of muscular strengthening with the orthosis connected to the phone app associated

with instrumented Orthosis

Eligibility Criteria

Age50 Years - 80 Years
Sexall
Healthy VolunteersNo
Age GroupsAdult (18-64), Older Adult (65+)

You may qualify if:

  • Person who signed informative consent
  • Affiliated with the social security
  • Male and female aged between 50 and 80
  • Walk without assistance
  • Smartphone's use

You may not qualify if:

  • Person under protective measure
  • Orthopedics issues
  • Neurologic issues (MMSE Test \< 24)
  • Knee or hip prothesis
  • Person with NSAIDs and analgesics treatment with an effective intake less than 48 hours before the evaluation
  • Predominant patello-femoral arthritis
  • Symptomatic hip OA
  • Knee infection
  • Knee injuries

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

CHU de Nice

Nice, 06000, France

Location

Related Publications (1)

  • Reneaud N, Zory R, Guerin O, Thomas L, Colson SS, Gerus P, Chorin F. Validation of 3D Knee Kinematics during Gait on Treadmill with an Instrumented Knee Brace. Sensors (Basel). 2023 Feb 6;23(4):1812. doi: 10.3390/s23041812.

MeSH Terms

Conditions

Osteoarthritis, Knee

Condition Hierarchy (Ancestors)

OsteoarthritisArthritisJoint DiseasesMusculoskeletal DiseasesRheumatic Diseases

Study Officials

  • Olivier GUERIN, MD

    Nice University Hospital

    PRINCIPAL INVESTIGATOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
SUPPORTIVE CARE
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

January 7, 2020

First Posted

January 13, 2020

Study Start

January 22, 2020

Primary Completion

June 2, 2022

Study Completion

June 2, 2022

Last Updated

March 24, 2026

Record last verified: 2026-03

Locations